PDF download Download the whole Issue

ORIGINAL RESEARCH

Features of sarcoidosis of the lungs and intrathoracic lymph nodes, combined with coronary heart disease. Abubikirov A.F. (Russia, Moscow), Zaitseva A.S.(Russia, Moscow), Leonova E.I. (Russia, Moscow), Mazaeva L.A. (Russia, Moscow), Medvedev A.V. (Russia, Moscow), Shmeleva N.M. (Russia, Moscow), Shmelev E.I. (Russia, Moscow) P.8

The influence of information devices and social environment factors on speech development in early age children. Belousova M.V. (Russia, Kazan), Shvets E.V. (Russia, Moscow) P.15

The impact of duodenogastric reflux on gastrinproducing cell quantity and on other morphological features of chronic gastritis. Galiev Sh.Z. (Russia, Kazan), Amirov N.B. (Russia, Kazan), Akhmetov T.R. (Russia, Kazan), Petrov S.V. (Russia, Kazan), Amirova R.N. (Russia, Kazan) P.21

Mobile planovalgus deformity treatment results in children. Dubrovin G.M. (Russia, Kursk), Bakurskaya E.S.(Russia, Kursk), Borovleva A.V. (Russia, Kursk) P.28

The impact of the second breakfast on the frequency of hypoglycemic states in patients with type II diabetes mellitus and acute myocardial infarction with Q-wave, receiving sulphonylurea medications. Ivanova L.A. (Russia, Krasnodar), Sokueva Kh.Yu.(Russia, Krasnodar), Korol I.V. (Russia, Krasnodar) P.33

Neural network application for cerebral palsy prediction in children based on perinatal factor influence evaluation. Orlova E.V. (Russia, Rostov-on-Don), Dudnikova E.V. (Russia, Rostov-on-Don), Vodopyanov A.S. (Russia, Rostov-on-Don),Chernova M.S. (Russia, Rostov-on-Don) P.40

The impact of the second clinical stage on ineffective prosthetic treatment in full overdenture restoration. Panakhov N.A. (Azerbaijan, Baku), Bayramov Yu.I. (Azerbaijan, Baku), Musayev E.R.(Azerbaijan, Baku) P.44

Respiratory diseases in industrial region of Siberia: morbidity analysis on the example of the Kemerovo region. Khanin A.L. (Russia, Novokuznetsk), Shabina O.P. (Russia, Novokuznetsk), Viktorova I.B. (Russia, Novokuznetsk) P.48

Gender identification by individual blade bone parameters. Chertovsky A.A. (Russia, Moscow),Tuchik E.S. (Russia, Moscow) P.53

New approaches to prevent and treat incresed serum lipids. Shah M. (Pakistan, Islamabad), Mastoi I.M. (Pakistan, Islamabad), Arain A.Q. (Pakistan, Islamabad), Shafique A. (Pakistan, Islamabad), Aslam H. (Pakistan, Islamabad), Niazi A.Kh.(Pakistan, Islamabad) P.56

PRESS RELEASE (RUSSIAN ONLY)

ORGANIZATION OF HEALTHCARE

Assessment of health center risks, related to medical care delivery in therapeutic departments. Kharisov A.M. (Russia, Odintsovo), Berseneva E.A.(Russia, Moscow), Bereznikov A.V. (Russia, Moscow), Shkitin S.O. (Russia, Moscow), Skiba Ya.В.(Russia, Odintsovo), Klimov Yu.A. (Russia, Podolsk) P.61

EXPERIMENTAL STUDIES – TO CLINICAL MEDICINE

The effect of sodium chondroitin sulfate and betamethasone on articular cartilage remodeling in experimental osteoarthritis. Kabalyk M.A. (Russia, Vladivostok), Nevzorova V.A. (Russia, Vladivostok), Tsygankov M.A. (Russia, Vladivostok),Dubov V.S. (Russia, Vladivostok) P.67

CLINICAL CASE

Long-term fever as a manifestation of drug intolerance in patients with nontuberculous pulmonary mycobacteriosis (clinical case). Degtyareva S.A.(Russia, Moscow), Shmelev E.I. (Russia, Moscow), Stepanyan I.E. (Russia, Moscow), Vladimirova E.B. (Russia, Moscow), Kovalevskaya M.N.(Russia, Moscow), Kasimtseva S.A. (Russia, Moscow), Hergert V.I. (Russia, Moscow) P.74

Surgical treatment of the leak of distal tibiofibular syndesmosis after ankle fracture (clinical case).Mikhailov S.V. (Russia, St. Petersburg), Khominets V.V. (Russia, St. Petersburg), Shakun D.A.(Russia, St. Petersburg), Shchukin A.V. (Russia, St. Petersburg), Foos I.V. (Russia, St. Petersburg), Komarov A.V. (Russia, Krasnoyarsk) P.78

Radicular cyst in the practice of pediatric dentist, management plan. Modina T.N. (Russia, Moscow), Tsinecker D.A. (Russia, Kazan), Tsinecker D.T.(Russia, Saint Petersburg), Kuznetsov E.A. (Russia, Saint Petersburg) P.83

___

ORIGINAL RESEARCH

UDC [616.24+616.428]-002.282:616.12-005.4

DOI: 10.20969/VSKM.2019.12(3).7-15

PDF download FEATURES OF SARCOIDOSIS OF THE LUNGS AND INTRATHORACIC LYMPH NODES, COMBINED WITH CORONARY HEART DISEASE

ABUBIKIROV ANVER F., C. Med. Sci., senior research worker of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: abubik_1@mail.ru

ZAITSEVA ANNA S., C. Med. Sci., senior research worker of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, 107564, Russia, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: anyasyls@yandex.ru

LEONOVA ELENA I., C. Med. Sci., research worker of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: zei86@mail.ru

MAZAEVA LARISA A., C. Med. Sci., research worker of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: lara.mazaeva@yandex.ru

MEDVEDEV ALEXANDER V., C. Med. Sci., senior research worker of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: alexmedved_1@mail.ru

SHMELEVA NATALIA M., C. Med. Sci., senior research worker of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: 09shmeleva@mail.ru

SHMELEV EVGENY I., D. Med. Sci., Head of the Department of tuberculosis differential diagnosis and extracorporeal treatment of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-08, e-mail: eishmelev@mail.ru

Abstract. Aim. The aim of the research was to study clinical, radiological, and functional parameters in patients with lung and intrathoracic lymph node sarcoidosis in combination with coronary heart disease. The nature of lung sarcoidosis clinical, radiological and functional manifestations in the presence of comorbid heart disease was analyzed. Material and methods. The study involved patients with lung and intrathoracic lymph node sarcoidosis divided into two groups. The first main group consisted of patients with lung sarcoidosis and coronary heart disease as a concomitant pathology. The second comparison group was represented by patients with lung sarcoidosis without coronary heart disease. The diagnosis of pulmonary sarcoidosis was made based on clinical indicators, and the results of radiological studies (chest X-ray, chest computed tomography). Some patients had a morphological verification of the diagnosis. The presence of coronary heart disease was confirmed by typical clinical signs, electrocardiographic and echocardiographic changes. 6-minute walk test, spirometry, body plethysmography, and lung diffusion capacity evaluation was performed to assess the functional status. Results and discussion. Respiratory symptoms were more pronounced and they developed in ashorter time in patients with coronary heart disease. Physical exercise tolerance in this group was significantly lower than in the main group. Spirometry and body plethysmography indicators did not differ between the groups. Lung diffusivity was significantly lower in the group with coronary heart disease. This may be due to development of interstitial edema and microcirculatory disorders at alveolar-capillary membrane level. Moderate pulmonary hypertension was detected in both groups, with no significant difference between them. Conclusion. The presence of coronary heart disease inpatients with lung sarcoidosis worsens and accelerates respiratory symptom development. It leads to exercise tolerance significant reduction and causes more pronounced diffusion disorders.

Key words: lung sarcoidosis, ischemic heart disease, spirometry, lung diffusion capacity, pulmonary hypertension.For reference: Abubikirov AF, Zaitseva AS, Leonova EI, Mazaeva LA, Medvedev AV, Shmeleva NM, Shmelev EI. Features of sarcoidosis of the lungs and intrathoracic lymph nodes, combined with coronary heart disease. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 7-15. DOI: 10.20969/VSKM.2019.12(3).7-15.

REFERENCES

1. Ivanova D.A., Borisov S.E., Nedostup A.V. Porazhenie serdca pri sarkoidoze: klinicheskie osobennosti, vliyanie steroidnoj terapii. [Damage of heart at a sarcoidosis: clinical features, influence of steroid therapy]. Problemy tuberkulyoza. [Tuberculosis problems]. 2009; 2: 22-28.

2. Hoitsma E, Faber C.G, van Kroonenbung M.J. Association of small fifer neuropathy with cardiac sympathetic dysfunction in sarcoidosis. Sarcoidosis Vasc. Diffuse Dis. 2005; 22(1): 43-51.

3. A.A. Vizel. Sarkoidoz: ot gipotezy k praktike. [Sarcoidosis: from a hypothesis to the practice]. Monografiya. Pod redakciej A.A. Vizelya.Monograph. [Under A.A. Vizel’s edition]. Kazan’. FEN. [ Kazan. FEN]. 2004.

4. Schulte W., Kristen D., Drent M., Costabel U. Cardiac involvement in sarcoidosis. Eur. Respir. Monograph. 2005; 32 :130-149.

5. Patel N, Apopa G, Apora P, Kalra R, Doshi R. Risk of cardiovascular disease among patient with sarcoidosis: a population – based retrospective cohort study – 1976-2013 years. J. Am. Heart Assoc. 2018 Jan 22:7(2) pii e007844, doi: 10.1116/JAHA. 117.007844

6. Rossman M.D. Kreider M.E. State of the art lesson learned from ACCESS (A case Controlled Etiologic Study of Sarcoidosis). Proc. Am. Thorac. Soc. 2007; 4 (5): 453-456.

7. Duong H., Bonham C.A. Sarcoidosis-associated Pulmonary Hypertension: Pathophysiology, Diagnosis, and Treatment. Clin Pulm Med. 2018 Mar; 25(2): 52–60.

8. Ilkovich M.M., Baranova O.P., Speranskiy A.A. Legochnaya gipertenziya pri sarkoidoze organov dyhaniya. [Pulmonary hypertensia at a sarcoidosis of a respiratory organs]. Medicinskij sovet. [Medical council]. 2014; 4: 12-16.

9. Stabil’naya ishemicheskaya bolezn’ serdca. [Stable coronary heart disease]. Klinicheskie rekomendacii. [Clinical recommendations]. Medicina. [Medicine]. M. 2016; 51.

10. Ageev A.T., Skvortsov N.A. Serdechnaya nedostatochnost’ na fone IBS. Nekotorye voprosy patogeneza i lecheniya [Heart failure against the background of an ischemic heart disease. Some questions of a pathogeny and treatment]. Russkij medicinskij zhurnal. [Russian medical magazine]. 2000; 15: 622-626.

11. Laohaburanaki P, Clan A. Obstructive sarcoidosis. Clin. Rev. Allergy Immunol. 2013; 25(2): 115 – 130.

12. Bicanic V Et al. Functional diagnosis of pulmonary sarcoidosis. Plucne Bolesti. 2009; 41(1-2): 18 -21.

13. Borisov S.E., Solivieva I.P., Goncharova E.V. Morfologicheskaya harakteristika sarkoidoza i osobennosti ego diagnostiki pri razlichnyh lokalizaciyah processa. [Morphological characteristic of a sarcoidosis and feature of its diagnostics at various localizations of process]. Sarkoidoz: ot gipotezy k praktike. Pod redakciej A.A. Vizelya. [Sarcoidosis: from a hypothesis to practice. Under A.A. Vizel’s edition]. Kazan’. FEN. [Kazan, FEN], 2004; 55-64.

14. Dmitrieva L.I., Sigaev A.T., Romanov V.V. Luchevaya diagnostika sarkoidoza organov dyhaniya. [Radiodiagnosis of a sarcoidosis of a respiratory organs]. Problemy tuberkuleza [ Tuberculosis problems]. 2001; 2: 56-61.

 

UDC 616.89-008.434-053.3/.4:004

DOI: 10.20969/VSKM.2019.12(3).15-20

PDF download THE INFLUENCE OF INFORMATION DEVICES AND SOCIAL ENVIRONMENT FACTORS ON SPEECH DEVELOPMENT IN EARLY AGE CHILDREN

BELOUSOVA MARINA V., C. Med. Sci., associate professor of the Department of psychotherapy and addictions of Kazan State Medical Academy – the branch of Russian Medical Academy of Postgraduate Education, Russia, 420061, Kazan, Ershov str., 49, tel. (843)272-41-51, e-mail: belousova.marina@mail.ru

SHVETS ELIZAVETA V., associate researcher of laboratory of speech psychology and psycholinguistics of Institute of psychology of the Russian Academy of Sciences, Russia, Moscow, Yaroslavskaya str., 13, tel. 8-903-771-57-83, e-mail: ferly1995@mail.ru

Abstract. The article considers the impact of modern information technology world on speech development in early age children. The main component is the fact of using information devices, and gadgets, by children aged 1 to 3,5 years. Aim. The aim of the study was to analyze speech development in young children from perspective of the influence of information devices and certain social environment components. Material and methods. The study included families with children aged 1 to 3,5 years. Three psychological diagnostic tools were applied in the course of the study, those were Nancy Bayley’s scale of psychomotor development in children; Home scale, developed by Betty Caldwell and Robert Bradley, aiming for assessment of the impact of environment via watching at home; as well as «Your child and his free time» Questionnaire for interviewing parents. Results and discussion. Interrelation between child speech development and the use of information devices was revealed in two groups out of three studied, those were the group of children with a specified level of speech development and the one with low level speech development. There was also an interrelation between speech development and certain components of social environment and mother care indicators. Conclusion. Uncontrolled use of information devices by children does not contribute to active development of speech. Adequate parent demanding attitude to their children can be a factor that has a positive impact on speech development. The key factors that have a positive impact on the speech development in children are active position of the mother and diversity of educational environment.

Key words: speech, information devices (gadgets), social factors (components), speech development level.

For reference: Belousova MV, Shvets EV. The influence of information devices and social environment factors on speech development in early age children. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 15-20. DOI: 10.20969/VSKM.2019.12(3).15-20.

REFERENCES

  1. Salwa S Al-Harbi. The Influence of Media in Children’s Language Development. Journal of Educational and Developmental Psychology. 2015; 5 (1): 1-5.
  2. Twenge Jean M. Generation Me. NY: ATRIA Paperback. 2014; 365 p.
  3. Hsin CT, Li MC, Tsai CC. The Influence of Young Children’s Use of Technology on Their Learning: A Review. Educational Technology and Society. 2014; 17 (4): 85-99.
  4. Avramenko OV. Informacionnye tekhnologii kak didakticheskaya podderzhka raboty po razvitiyu rechi detej [Information technology as a didactic support on work on the language development of children]. Uspekhi sovremennoj nauki i obrazovaniya [Success of modern science and education]. 2016; 1 (7): 105-110.
  5. Belousova MV, Karpov AM, Utkuzova MA. Vliyanie gadzhetov na razvitie kommunikacii, socializacii i rechi u detej rannego i doshkol’nogo vozrasta [Influence of gadgets on communication, socialization and speech development in infants and preschool children]. Prakticheskaya medicina [Practical medicine]. 2014; 9 (85): 108-112.
  6. Hobson RP, Caldwell B. The grounding of symbols: A social developmental account. In P. Mitchell & K. J. Riggs (Eds.), Children’s reasoning and the mind. Psychology Press. 2000; 11-35.
  7. Karabanova OA. Social’naya situaciya razvitiya kak preodolenie dihotomii «lichnost’—sreda» [Social situa-tion of development as a factor of overcoming thedichotomy «personality-environment»]. Psihologicheskie issledovaniya: elektronnii nauchnii zhurnal [Psychological research: electronic scientific journal]. 2014; 7 (36): 10-16.
  8. Shvets EV. Vzaimosvyaz’ komponentov social’noj sredy i urovnya rechevogo razvitiya na rannih etapah ontogeneza [The interrelation between the com-ponents of social environment and the level of speechdevelopment at early stages of ontogenesis]. Collegium Linguisticum-2017: tezisy dokladov ezhegodnoj konferencii Studencheskogo nauchnogo obshchestva MGLU [Collegium Linguisticum-2017: abstracts of the annual conference of the student scientific society of Moscow State Linguistic University]. Moskva: Moskovskiy Gosudarstvennyy Lingvisticheskiy Universitet [Moscow: Moscow State Linguistic University]. 2017; 132.
  9. Shvets EV. Social’naya sreda kak faktor rechevogo razvitiya na rannih etapah ontogeneza [Social environment as a factor of speech development at early stages of ontogenesis]. Collegium Linguisticum-2016: tezisy dokladov ezhegodnoj konferencii Ctudencheskogo nauchnogo obshchestva Moskovskоgo Gosudarstvennogo Lingvisticheskogo Universiteta [Collegium Linguisticum-2016: abstracts of the annual conference of the student scientific society of Moscow State Linguistic University]. Moskva: Moskovskiy Gosudarstvennyy Lingvisticheskiy Universitet [Moscow: Moscow State Linguistic University]. 2016; 54-55.
  10. Bayley N. Bayley Scales of Infant Development. NY: Psychological Corporation. 1966; 178 p.
  11. Bradley R. Home Observation for Measurement of the Environment: A Validation Study of Screening Efficiency. American Journal of Mental Deficiency.1977; 417-420.
  12. Belousova MV, Merkulova VA, Gavrikova IYu. Programma razvitiya upravlyayushchih funkcij mozga [Program for the development of brain control functions]. Kazan’: Veda [Kazan: Veda]. 2013; 313 p.

 

UDC 616.342-008.17-031:611.33

DOI: 10.20969/VSKM.2019.12(3).20-28

PDF download THE IMPACT OF DUODENOGASTRIC REFLUX ON GASTRIN-PRODUCING CELL QUANTITY AND ON OTHER MORPHOLOGICAL FEATURES OF CHRONIC GASTRITIS

GALIEV SHAMIL Z., postgraduate student of the Department of general medical practice of Kazan State Medical University, Russia, Kazan, Butlerov str., 49, tel. 8-927-421-03-08, e-mail: galis160@gmail.com

AMIROV NAIL B., ORCID ID: 0000-0003-0009-9103; D. Мed. Sci., professor of the Department of general medical practice of Kazan State Medical University, Russia, Kazan, Butlerov str., 49, tel. 8-905-313-01-11, e-mail: namirov@mail.ru

AKHMETOV TIMUR R., C. Med. Sci., Republic Clinical Cancer Center, Russia, 420029, Kazan, Sibirskiy tract str., 29, e-mail: timur1111@mail.ru

PETROV SEMEN V., D. Мed. Sci., professor, Republic Clinical Cancer Center, Russia, 420029, Kazan, Sibirskiy tract str., 29, e-mail: semyonp@mail.ru

AMIROVA RENATA N., medical officer «SOGAZ» OJSC, Russia, Kazan, tel. + 7-903-307-99-47, e-mail: renata1980@mail.ru

Abstract. Aim. The aim of the study was to identify the nature of the impact of duodenogastric reflux and H. pylori on acidity level, gastrin-producing (G) cell quantitative indicators and other morphological changes in gastric mucosa in «primary» reflux gastritis. Material and methods. 66 patients with reflux gastritis were examined. 15 people were enrolled in control group. All patients underwent esophagogastroduodenoscopy with determination of acidity and bile acid concentration in the gastric content. Gastric mucosa biopsy material histological examination was performed in 55 cases. Additionally, histochemical (Schiff-iodic acid and alcian blue) staining and immunohistochemical studies (gastrin, cytokeratin 20, villin, MUC2, and cancer embryonic antigen expression determination) were carried out in 25 cases.Results and discussion. Acidity level was higher in patients with duodenogastric reflux (pH 3,47±2,37) comparing to control group (pH 5,73±1,91). As for the morphological features of duodenogastric reflux, mononuclear infiltration (p=0,001), foveolar hyperplasia (p=0,001) in all parts of the stomach, antral edema (p=0,022) and atrophy (p=0,02), intestinal metaplasia (p=0,022) at the level of the body of the stomach significantly differed from control group. G-cell hyperplasia in the antral mucous membrane was detected in patients with DGR (p=0,016). In patients with gastritis, caused jointly by duodenogastric reflux and H. pylori infection, the percentage of G-cells in gland epithelium did not differ from the control group (p=0,776). Conclusion. The mechanisms of morphological changes in duodenogastricreflux are associated with G-cell hyperplasia. Duodenogastric reflux contributes to the «acidification» of gastric content.Key words: duodenogastric reflux, gastrin-producing cells, acidity, chronic gastritis

For reference: Galiev ShZ, Amirov NB, Akhmetov TR, Petrov SV, Amirova RN. The impact of duodenogastric reflux on gastrin-producing cell quantity and on other morphological features of chronic gastritis. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 20-28. DOI: 10.20969/VSKM.2019.12(3).20-28.

REFERENCES

1. Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015; 64: 1353–1367.

2. Volkov VS, Kolesnikova IYu. Duodenogastral’nyy reflyuks i yazvennaya bolezn’ dvenadtsatiperstnoy kishki – rasstavim tochki nad «i» [Duodenogastric refl ux and duodenal ulcer dot the i’s]. Verkhnevolzhskiy meditsinskiy zhurnal [Upper Volga medical journal]. 2010; 8 (1): 26–29.

3. Sjövall H. Meaningful or redundant complexity - mechanisms behind cyclic changes in gastroduodenal pH in the fasting state. Acta Physiol (Oxf). 2011; 201 (1):127-131.

4. Vakhrushev YaM, Nikishina YeV. Kompleksnoye izucheniye patogeneticheskikh mekhanizmov erozivnogo porazheniya zheludka i dvenadtsatiperstnoy kishki [A comprehensive study of the pathogenetic mechanisms

of erosive lesions of the stomach and duodenum]. Pocsiyskiy gastroenterologicheskiy zhurnal [Russian gastroenterological journal]. 1998; 3: 22-29.

5. Fein M, Fuchs K-H, Bohrer T, Freys SM, Thiede A. Fiberoptis technique for the 24-hour bile refl ux monitoring. Dig Dis Sci. 1996; 41 (1): 216-225.

6. Matsuhisa T, Arakawa T, Watanabe T, Tokutomi T, Sakurai K, Okamura S, et al. Relation between bile acid refl ux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: a multicenter study of 2283 cases. Dig Endosc. 2013; 25 (5): 519-525.

7. Dixon MF, O’Connor HJ, Axon ATR, King RFJG, Johnston D. Refl ux gastritis: distinct histopathological entity? J Clin Pathol. 1986; 39: 524-530.

8. Kolesnikova IYu, Volkov VS, Lyubskaya LA. Osobennosti duodenogastral’nogo refl yuksa pri yazvennoy bolezni dvenadtsatiperstnoy kishki i yego dinamika posle eradikatsii Helicobacter pylori [Features of duodenogastric reflux in duodenal ulcer and its dynamics after Helicobacter pylori eradication]. Eksperimental’naya i klinicheskaya gastroenterologiya [Experimental and clinical gastroenterology]. 2011; 5: 16–19.

9. Chen SL, Mo JZ, Cao ZJ, Chen XY, Xiao SD. Effects of bile reflux on gastric mucosal lesions in patients with dyspepsia or chronic gastritis. World J Gastroenterol. 2005; 11 (18): 2834–2847.

10. Orlando LA, Lenard L, Priando RC. Chronic hypergastrinemia causes and consequences. Dig Dis Sci. 2007; 42 (9): 1031-1039.

11. Dacha S, Razvi M, Massaad J, Cai Q, Wehbi M. Hypergastrinemia. Gastroenterology Report. 2015; 3 (3): 201–208.

12. Zavros V, Reider G, Ferguson A, Samuelson LC, Merchant JL. Hypergastrinemia in respons to gastric infl ammation suppresses somatostatin. Am J Physiol Gastrointest Liver Physiol. 2002; 282: 175-183.

13. Stepanov YuM, Mosiychuk LN, Kovalenko AN. Soderzhaniye syvorotochnogo gastrina u patsiyentov s reflyuks-gastritom [The content of serum gastrin in patients with reflux gastritis]. Gastroenterologiya [Gastroenterology]. 2014; 2 (52): 32-36.

14. Kaminishi M, Sadatsuki H, Johjima Y, Oohara T, Kondo Y. A new model for production of chronic gastric ulcer by duodenogastric refl ux in rats. Gastroenterol. 1987; 92: 1913−1918.

15. Wetscher GJ, Hinder RA, Kretchmar D, Stinson R, Perdikis G, et al. Duodenogastric refl ux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade. Digestive Diseases and Sciences. 1996; 41 (11): 2166-2173.

16. Gasslander T, Mukaida H, Herrington MK, Hinder RA, Adrian TE. Profound duodenogastric reflux causes pancreatic growth in rats. Gut. 1995; 36: 137-141.

17. Thomas WE, Ardill J, Buchanan KD. Suppression of somatostatin release by duodenogastric refl ux in dogs. Gut. 1984; 25: 1230-1233.

18. Thompson JN, Barr JA, Collier N, Spenser J, Bush A, Cope L, et al. Basal, sham feed and pentagastrin stimulated gastric acid, pepsin and electrolytes after omeprazole 20 mg and 40 mg daily. Gut. 1985; 26: 1018-1024.

19. Lorusso D, Misciagna G, Mangini V, Messa C, Cavallini A, Caruso ML, et al. Duodenogastric refl ux of bile acids, gastrin and parietal cells, and gastric acid secretion before and 6 months after cholecystectomy. Am J Surg. 1990; 159: 575-578.

20. Galiyev ShZ, Amirov NB. Duodenogastral’nyy refl yuks kak prichina razvitiya refl yuks-gastrita [Duodenogastric refl ux as a cause of the development of refl ux gastritis]. Vestnik sovremennoy klinicheskoy meditsiny [The Bulletin of Contemporary Clinical Medicine]. 2015; 8 (2): 50-61.

21. Kononov AV, Mozgovoy SI, Shimanskaya AG, Grishchenko RK, Nazarov AN. Immunogistokhimicheskaya detektsiya biomolekulyarnykh markerov metaplasticheskoy atrofii slizistoy obolochki v gastrobioptatakh [Immunohistochemical detection of biomolecular markers of metaplastic mucosal atrophy in gastrobiopathies]. Arkhiv patologii [Archive Pathology]. 2014; 6: 44-50.

22. Mozgovoy SI. Kishechnaya metaplaziya slizistoy obolochki zheludka: ot prirody fenomena k prognozu [Intestinal metaplasia of the gastric mucosa: from the nature of the phenomenon to the forecast]. Byulleten’ SO RAMN [Bulletin of the SB RAMS]. 2009; 3 (137): 5-9.

23. Rasband W. Image J: image processing and analysis in Java. Bethesda: National Institute of Mental Health. 2012; https://www.researchgate.net/publication/258729119_ImageJ_-_Image_Processing_and_Analysis_in_Java

24. Zhang Y, Yang X, Gu W, Shu X, Zhang T, Jiang M. Histological features of the gastric mucosa in children with primary bile refl ux gastritis. World J Surg Oncol. 2012; 10: 27.

25. Wang X, Tang J, Cao Q. The effects of chronic bile reflux on the gastric mucosa of rats. Turk J Gastroenterol. 2013; 24 (3): 251-259.

26. Tzaneva M. Effects of duodenogastric refl ux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa. Pathol Res Pract. 2004; 200 (6): 431-438.

27. Galiyev ShZ, Amirov NB, Baranova OA. Morfologicheskiye priznaki refl yuks-gastrita [Morphological signs of reflux gastritiss]. Kazanskiy meditsinskiy zhurnal [Kazan Medical Journal]. 2017; 98 (4): 533-538.

28. Liu Y, Vosmaer GDC, Tytgat GNJ, Xiao S-d, Ten Kate FJW. Gastrin (G) cells and somatostatin (D) cells in patients with dyspeptic symptoms: Helicobacter pylori associated and non-associated gastritis. J Clin Pathol. 2005; 58: 927–931.

29. Tel’nyh JuV, Abgadzhava JeZ, Kon’kov MJu. Biliarnyy refl yuks-gastrit: etiologiya, patogenez i sovremennyye printsipy terapii [Biliary reflux-gastritis: etiology, pathogenesis and modern principles of treatment].

Klinicheskaya meditsina [Clinical medicine]. 2016; 94 (6): 454—457.

 

DOI: 10.20969/VSKM.2019.12(3).28-33

PDF download MOBILE PLANOVALGUS DEFORMITY TREATMENT RESULTS IN CHILDREN

DUBROVIN GRIGORY M., D. Med. Sci., professor, Head of the Department of traumatology and orthopedics of Kursk State Medical University, Russia, 305004, Kursk, K. Marx str., 3, e-mail: grig-d31@yandex.ru

BAKURSKAYA EKATERINA S., 3rd year postgraduate student of the Department of traumatology and orthopedics of Kursk State Medical University, Russia, 305004, Kursk, K. Marx str., 3, e-mail: katya_bakurskaya@mail.ru

BOROVLEVA ANNA V., 6th year student of faculty of general medicine of Kursk State Medical University, Russia, 305004, Kursk, K. Marx str., 3, e-mail: borovleva_anna@rambler.ru

Abstract. Aim. The aim of the research was to study the results of mobile planovalgus deformity treatment in differenttypes of feet pronation correction. Material and methods. We examined 102 children with mobile planovalgus deformity between the ages of 5 and 10 years, divided into 3 clinical groups. The main difference in the main group was the application of individual corrective insoles manufactured according to our own methods. Standard corrective insoles were used in the first control group, with no use of orthoses in the second control group against the background of administration of a standard complex of massage, physical exercises and physiotherapy procedures. Results and discussion. The results of treatment were evaluated by 3 indicators: subsurface index, valgus deviation of the calcaneus, and height of the internal ankle standing. The most reliable changes in all three indicators were achieved in the main group, whereas in both control groups only the change in the sub-index was reliable. Conclusion. It hasbeen established that the application of corrective insoles manufactured according to our own methods in children withmobile planovalgus deformity significantly improves the performance of the subsurface index, reduces the pronation angle of calcaneus and increases the height of the internal ankle.

Key words: mobile planovalgus deformation, individual corrective insoles, standard corrective insoles, valgus foot correction.

For reference: Dubrovin GM, Bakurskaya ES, Borovleva AV. Mobile planovalgus deformity treatment results in children. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 28-33. DOI: 10.20969/VSKM.2019.12(3).28-33.

REFERENCES

1. Mironov SP ed. Klinicheskie rekomendacii: Travmatologiya i ortopediya detskogo vozrasta [Clinical recommendations: Traumatology and orthopedics of children’s age]. Moskva: GEOTAR-Media [Moscow: GEOTAR-Media]. 2017; 417 р.
2. Bauer K, Mosca VS, Zionts LE. What’s New in Pediatric Flatfoot? Journal of Pediatric Orthopaedics. 2016; 36 (8): 865-869.
3. Bocahut N, Simon AL, Mazda K, Ilharreborde B, Souchet P. Medial to posterior release procedure after failure of functional treatment in clubfoot: a prospective study. Journal of Children’s Orthopaedics. 2016; 10 (2): 109-117.
4. Soomekh DJ, Baravarian B. Pediatric and adult flatfoot reconstruction: subtalar arthroereisis versus realignment osteotomy surgical options. Clinics in Podiatric Medicine and Surgery. 2006; 23 (4): 695-708.
5. Kenis VM, Lapkin YuA, Husainov RH, Sapogovskij AV. Mobil’noe ploskostopie u detej (obzor literatury) [Mobile flatfoot in children (literature review)]. Ortopediya, travmatologiya i vosstanovitel’naya hirurgiya detskogo vozrasta [Orthopedics, Traumatology and Reconstructive Surgery of Children]. 2014; 2 (2): 44-54.
6. Wagner F, Hofbauer R, Matussek J. Flexible flatfoot in children: variation within normal range or need for treatment? Orthopade. 2013; 42 (6): 455-468.
7. Bol’shakov OP, Kotov IR, Polyakova EL. Forma stopy detej 2–5 let po dannym plantometrii i golograficheskoj interferometrii [The shape of the foot of children 2–5 years old according to plantometry and holographic interferometry]. Morfologiya [Morfology]. 2014; 4: 64-69.
8. MacKenzie А, Rome K, Evans A. The Efficacy of Nonsurgical Interventions for Pediatric Flexible Flat Foot: A Critical Review. Journal of Pediatric Orthopaedics B. 2012; 32 (8): 830-834.
9. Egorova SA, Petryakova VG. Novyj vzglyad na prichiny ploskostopiya i ego profilaktiku sredstvami fizicheskoj kul’tury [A new look at the causes of flatfoot and its prevention by means of physical culture]. Vestnik Stavropol’skogo gosudarstvennogo universiteta [Bulletin of Stavropol State University]. 2010; 1: 47-51.
10. Shih YF, Chen CY, Chen WY, et al. Lower extremity kinematics in children with and without flexible flatfoot: a comparative study. BMC Musculoskelet Disorders. 2012; 13: 31-40.
11. Benedetti MY, Cecarelli F, Berti L, Luciani D, Catani F, Boschi M, Giannini S. Diagnosis of flexible flatfoot in children: a systematic clinical approach. Orthopedics. 2011; 34: 94-105.
12. Bouchard M, Mosca VS. Flatfoot deformity in children and adolescents: surgical indications and management. The Journal of the American Academy of Orthopaedic Surgeons. 2014; 10: 623-632.
13. Ekcali O, Kosay C, Kaner B, Arslan Y, Sagol E, Soylev S, Iyidogan D, Cinar N, Peker O. Flexible flatfoot and related factors in primary school children: a report of ascreening study Rheumatology Internetional. 2006; 26: 1050-1053.
14. Bakurskaya ES, Dubrovin GM. Ustrojstvo dlya diagnostiki sostoyaniya nizhnih konechnostej u detej [Device for diagnosing the state of the lower extremities in children]. Zayavka na patent No 2018117974 RF, MPK A 61V 5/107 A 61 V 5/13 – No 185901 [Patent application No 2018117974 RF,MPKA61V5/107A61V5/13–No185901].2018; 36: 10 р.

15. Bakurskaya ES, Dubrovin GM. Sposob izgotovleniya individual’noj ortopedicheskoj stel’ki pri plosko-val’gusnoj nefiksirovannoj deformacii stop [A method of manufacturing an individual orthopedic insole for flat-valgus unfixed deformation of the feet]. Zayavka na patent No 2017112463 RF,MKPA61F5/14A43B7/22–No2651701[Patent application No 2017112463 RF, MKP A 61 F 5/14 A 43 B 7/22 – No 2651701]. 2018; 12: 7 р.

16. Farzin Halabchi, Reza Mazaheri, Maryam Mirshahi, Ladan Abbasian. Pediatric Flexible Flatfoot; Clinical Aspects and Algorithmic. Iranian Journal of Pediatrics. 2013; 23 (3): 247–260.

 

UDC [616.379-008.64:616.127-005.8]-085.252.349.7-06

DOI: 10.20969/VSKM.2019.12(3).33-39

PDF download THE IMPACT OF THE SECOND BREAKFAST ON THE FREQUENCY OF HYPOGLYCEMIC STATES IN PATIENTS WITH TYPE II DIABETES MELLITUS AND ACUTE MYOCARDIAL INFARCTION WITH Q-WAVE, RECEIVING SULPHONYLUREA MEDICATIONS

IVANOVA LIUDMILA A., ORCID: 0000-0001-5302-3802; D. Med. Sci., professor, Head of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7 (988)242-13-90, e-mail: endocrinkgmu@mail.ru

SOKUEVA KHEDA YU., postgraduate student of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7 (928)738-38-82, e-mail: s.khaidi@yandex.ru

KOROL INNA V., ORCID: 0000-0002-3909-9007; C. Med. Sci., associate professor of the Department of endocrinology of faculty of advanced training and professional specialist retraining of Kuban State Medical University, Russia, 350063, Krasnodar, Sedin str., 4, tel. +7 (918)414-44-19, e-mail: innakorol1@mail.ru

Abstract. Aim. The aim of the study was to determine the frequency of hypoglycemic conditions in patients with type II diabetes and acute myocardial infarction with Q-wave receiving sulphonylurea medications, and to reduce their number by adding a second breakfast. Material and methods. The study included 90 patients [mean age (55±3,7) years] with type II diabetes mellitus and acute myocardial infarction with Q-wave. The patients were divided into 3 groups: patients of group 1 (n=30) were receiving gliclazide (mean daily dose 60 mg), group 2 (n=30) – micronized glybenclamide (mean daily dose 3,5 mg), group 3 (n=30) – glimepiride (mean daily dose 3 mg). At the first stage of the study the diet consisted of 3 main meals. At the second stage second breakfast was added 2 hours after morning sulphonylurea medication intake. Laboratory tests, electrocardiography and echocardiography were performed in all patients at both stages. Results and discussion. It was revealed that the frequency of hypoglycemic conditions is significantly higher in patients on three meals a day without snacking. Hypoglycemia occurred 2–2,5 hours after morning sulphonylurea drug intake. The highest frequency of hypoglycemia was observed in the group of patients receiving glybenclamide. After adding a second breakfast, hypoglycemia disappeared. Conclusion. Hypoglycemic condition frequency reduction in patients with type II diabetes and acute myocardial infarction with Q-wave receiving sulphonylurea medications is possible by adding a second breakfast, containing 12–15 grams of carbohydrates, at the drug action spike.

Key words: sulphonylurea medications, diabetes mellitus, hypoglycemic state.

For reference: Ivanova LA, Sokueva Khu, Korol IV. The impact of the second breakfast on the frequency of hypoglycemic states in patients with type 2 diabetes mellitus and acute myocardial infarction with Q-vawe, receiving sulphonylurea medications. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3):33-39. DOI: 10.20969/ VSKM.2019.12(3).33-39.

REFERENCES

  1. Whiting DR, Guariguata L, Weil C et al. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011; 94 (3): 311-321.

  2. Nam Han Cho ed. IDF Diabetes Atlas, 8th ed. Brussels: International Diabetes Federation. 2017; 150 p.

  3. Dedov II, Shestakova MV, Vikulova OK. Saharnyj diabet v Rossijskoj Federacii: rasprostanennost’, zabolevaemost’, smertnost’, parametry uglevodnogo obmena i struktura saharosnizhayushchej terapii po dannym Federal’nogo registra SD, status 2017 g [Diabetes mellitus in the Russian Federation: prevalence, morbidity, mortality, parameters ofcarbohydrate metabolism and structure of hypoglycemictherapy according to the Federal register of diabetes, status 2017]. Saharnyj diabet [Diabetes mellitus]. 2018; 3 (21): 144-159.

  4. Dedov II, Shestakova MV, Galstyan GR. Rasprostranennost’ saharnogo diabeta 2 tipa u vzroslogo naseleniya v Rossii (issledovanie NATION) [Prevalence of type 2 diabetes mellitus in adult population in Russia (NATION study)]. Saharnyj diabet [Diabetes mellitus]. 2016; 2 (19): 104-112.

  5. Bojcov SA, Pogosova NV, Bubnova MG. Kardiovaskulyarnaya profilaktika 2017; Rossijskie nacional’nye rekomendacii [Cardiovascular prevention 2017; Russian national recommendations]. Rossijskij kardiologicheskij zhurnal [Russian cardiological journal]. 2018; 6 (23): 7-122.

  6. Dedov II, Fadeev VV. Vvedenie v diabetologiyu: rukovodstvo dlya vrachej [Introduction to diabetology: a guide for physicians]. Moskva: Bereg [Moscow: Shore]. 2011; 200 p.

  7. Mkrtumyan AM. Vliyanie postprandial’noj glikemii na serdechnososudistuyu zabolevaemost’ saharnym diabetom 2 tipa i ee korrekciya [Effect of postprandial glycemia on cardiovascular incidence of type 2 diabetes mellitus and its correction]. Consilium medicum. 2004; 6 (9): 3-7.

  8. Abbud ZA. Effect of diabetes mellitus on short- and long-term mortality rates of patients with acute myocardialinfarction: a statewide study; Myocardial Infarction; Data Acquisition System Study Group. Journal Am Heart. 2009; 130 (51): 8.

  9. Smith SC, Allen J, Blair SN et al. AHA/ACC guidelines forsecondary prevention for patients with coronary and otheratherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Journal Circulation. 2006; 113 (22): 847.

  10. Ryden L, Standi E, Bartnilk L. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Journal Eur Heart. 2007; 28 (1): 88-136.

  11. Kalashnikov VYu, Vikulova OK, Zheleznyakova AV. Epidemiologiya serdechno-sosudistyh zabolevanij u bol’nyh saharnym diabetom po dannym Federal’nogo registra Rossijskoj Federacii (2013-2016 gg) [Epidemiology of cardiovascular diseases in patients with diabetes mellitusaccording to the Federal register of the Russian Federation (2013-2016]. Saharnyj diabet – pandemiya XXI sbornik tezisov VIII (XXV) Vserossijskogo diabetologicheskij kongress s mezhdunarodnym uchastiem: FGBU «NMIC endokrinologii» Minzdrava Rossii; OO «Rossijskaya associaciya endokrinologov» [Diabetes mellitus is the pandemic of the XXI abstracts VIII (XXV) of the diabetes all-Russian Congress with international participation: NMHC endocrinology of the Ministry of health of Russia; «Russian Association of endocrinologists»]. 2018; 10-11.

  12. David LA. Prognoz ostrogo infarkta miokarda v zavisimosti ot vozrasta i prisutstviya saharnogo diabeta [Prognosisof acute myocardial infarction depending on the age andpresence of diabetes]. Journal Medicinskij alfavit [Medical alphabet]. 2014; 2 (14): 54-57.

  13. David LA, Grosu AA, Radukan AM. Serdechno-sosudistaya smertnost’ i risk vnezapnoj smerti v postinfarktnom periode vyshe u bol’nyh saharnym diabetom [Cardiovascular mortality and the risk of sudden death in the post-infarction period is higher in patients with diabetes mellitus]. Evrazijskij kardiologicheskij zhurnal [Eurasian cardiology journal]. 2016; 3: 159-160.

  14. Sinyakova AK, Valeeva RM, Ivonina EV. Klinikodiagnosticheskie aspekty i gendernye otlichiya infarkta miokarda u bol’nyh saharnym diabetom 2 tipa [Clinical anddiagnostic aspects and gender differences of myocardialinfarction in patients with type 2 diabetes]. Journal Zdorov’e, demografiya, ekologiya finno-ugorskih narodov [Health, demography, ecology of the Finno-Ugric peoples]. 2014; 4: 39-43.

  15. Dedov II, Shestakova MV, Majorov AYu. Algoritmy specializirovannoj medicinskoj pomoshchi bol’nym saharnym diabetom: klinicheskie rekomendacii (8-j vypusk) [Algorithms of specialized medical care for patients with diabetes: clinical guidelines]. Saharnyj diabet [Diabetes mellitus]. 2017; 1: 1-121.

  16. Yamada M, Kurachi Y. The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels. Journal Mol Pharmacol. 2004; 65 (5): 1198–1207.

  17. Alekseenko EA, Bykov IM, Lukonin IA. Narusheniya okislitel’nogo metabolizma u bol’nyh saharnym diabetom 2-go tipa i zabolevaniyami organov dyhaniya [The oxidative metabolism disorders in patients suffering from type II diabetes mellitus and diseases of the respiratory apparatus]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scientific Medical Bulletin]. 2017; 1 (1): 7-11.

  18. Bykov IM, Ivchenko LG, Domenyuk DA et al. Osobennosti svobodnoradikal’nogo okisleniya i antioksidantnoj zashchity u detej s saharnym diabetom 2 tipa [Features of free radical oxidation and antioxidant protection in children with sugar diabetes of the first type]. Kubanskij nauchnyj medicinskij vestnik [Kuban Scientific Medical Bulletin]. 2017; (4): 27-38.

  19. Klepzig H, Kober G, Matter C, et al. Sulfonylureas and ischemic preconditioning: a double-blind, placebo-controlled evaluation of glimepiride and glibenclamide. Journal Eur Heart. 1999; 20: 439–446.

  20. Meier JJ, Deifuss S, Klamann A. Plasma glucose athospital admission and previous metabolic controldetermine myocardial infarct size and survival in patients with and without type 2 diabetes: the Langendreer Myocardial Infarction and Blood Glucose in Diabetic Patients Assessment (LAMBDA). Journal Diabetes care. 2005; 28 (10): 2551-2553.

 

UDC 616.831-009.11-053.2-037:004.032.26

DOI: 10.20969/VSKM.2019.12(3).40-43

PDF download NEURAL NETWORK APPLICATION FOR CEREBRAL PALSY PREDICTION IN CHILDREN BASED ON PERINATAL FACTOR INFLUENCE EVALUATION

ORLOVA ELENA V., Head of day care hospital for medical rehabilitation of Regional Pediatric Clinical Hospital, Russia, Rostov-on-Don, Strelcovaya Divizya 339 str., 14/168, e-mail: orlovae1@yandex.ru

DUDNIKOVA ELEONORA V., D. Med. Sci., professor, Head of the Department of pediatric diseases No 1 of Rostov State Medical University, Russia, Rostov-on-Don, Nakhichevan layn, 29, e-mail: kaf.det.bol.1@yandex.ru

VODOPYANOV ALEXEY S., C. Med. Sci., Rostov-on-Don Anti-Plague Institute of Federal Service on Surveillance for Consumer rights protection and human well-being, Russia, Rostov-on-Don, M. Gorky str., 117, e-mail: alexvod@gmail.com

CHERNOVA MARIA S., C. Med. Sci., assistant of professor of the Department of pediatric diseases No 1 of Rostov State Medical University, Russia, 101, Rostov-on-Don, Nakhichevan layn, 29, e-mail: marysia2005.87.11@mail.ru

Abstract. Aim. Development of a methodology and creation of a neural network software package for cerebral palsy risk prediction in children was the aim of the study. Material and methods. The study involved children with adiagnosis of cerebral palsy, confirmed by clinical, instrumental and laboratory study methods, as well as the children without diagnosed central nervous system diseases. In addition to primary medical documentation review, we surveyed mothers followed by filling out an individual card. Statistical data processing was carried out using Fisher’s exact test using StatisticaNeuralNetworks software package. The software was developed in Java programming language using the Encog 3.4 module. Results and discussion. Based on an artificial neural network, we developed a method assessing the influence of 20 perinatal factors on cerebral palsy development risk. The software package to be used in routine practice has been created in Java programming language, which allows quick cerebral palsy risk assessment.Conclusion. Statistically significant factors that influence cerebral palsy development risk in children were identified. We developed neural network classifier. Significance indicators of the parameters that had the greatest influence on the risk of cerebral palsy development in children were calculated. Test prediction of the developed expert system was also performed using control patient sample.

Key words: children, risk factors, cerebral palsy, artificial neural network.

For reference: Orlova EV, Dudnikova EV, Vodopyanov AS, Chernova MS. Neural network application for cerebral palsy prediction in children based on perinatal factor influence evaluation. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 40-43. DOI: 10.20969/VSKM.2019.12(3).40-43.

REFERENCES

1. Voronin GV, Pal’ceva EM, Ruanet VV, Hadarcev AA, Hetagurova AK. Nejrosetevye tekhnologii i voprosy identifikacii v medicinskih issledovaniyah; chast’ II [Neuro-network technologies and identification in medical research; part II.] Vestnik novyh medicinskih tekhnologij [Bulletin of new medical technologies]. 2009; 1: 33–34.

2. Efimova NV, Gornov AYu. Opyt ispol’zovaniya iskusstvennyh nejronnyh setej pri prognozirovanii zabolevaemosti naseleniya [Experiment using artificial neural networks in predicting the incidence of diseases within the population]. Ekologiya cheloveka [Human ecology]. 2010; 3: 3–7.

3. Litvin AA, Zharikov OG. Vozmozhnosti prognozirovaniya oslozhnennogo lecheniya ostrogo pankreatita [Predictingcapabilities for the complicated treatment of acutepancreatitis]. Novye tekhnologii v medicine [New technologies in medicine]. 2007; 1: 77–79.

4. Milova KA. Intellektual’naya sistema prognozirovaniya razvitiya oslozhnenij u hirurgicheskih bol’nyh [Intellectualsystem for predicting the development of complications insurgical patients]. Nejrokomp’yutery [Neuro-computers]. 2010; 11: 59–61.

5. Bogoslavskij SN. Oblast’ primeneniya iskusstvennyh nejronnyh setej i perspektivy ih razvitiya [Application scope of artificial neural networks and their development prospects]. Nauchnyj zhurnal KubGAU [Scientific journal of KubSAU]. 2007; 27: 20–27.

6. Voronin GV, Pal’ceva EM, Ruanet VV, Hadarcev AA, Hetagurova AK. Nejrosetevye tekhnologii i voprosy identifikacii v medicinskih issledovaniyah; chast’ I [Neural network technologies and identification in medical research; part I]. Vestnik novyh medicinskih tekhnologij [Bulletin of new medical technologies]. 2008; 4: 192–196.

7. Basova LA, Karyakina OE, Martynova NA, Kochorova LV. Prognozirovanie posleoperacionnyh oslozhnenij na osnove nejrosetevyh tekhnologij [Prediction of postoperative complications based on neural network technologies]. Vestnik novyh medicinskih tekhnologij [Bulletin of new medical technologies]. 2015; 22 (4): 117-121.

8. Zhilin VV. Prognozirovanie iskhoda procedury neinvazivnoj eliminacii konkrementov s ispol’zovaniem gibridnyh tekhnologij nechetkoj logiki prinyatiya reshenij i nejronnyh setej [Predicting the outcome of non-invasive elimination procedures of calculi using hybrid fuzzy decision-making logic and neural networks]. Kursk: Kurskiy gosudarstvennyy tekhnicheskiy universitet [Kursk: Kursk State Technical University]. 2009; 125 p.

9. Kruglov VV, Borisov VV. |Iskusstvennye nejronnye seti: teoriya i praktika [Artificial neural networks: theory and practice]. Moskva: Goryachaya liniyaTelekom [ Moscow: Hotline Telecom]. 2001; 382 p.

10. Kapsargin FP, Ershov AV, Zueva LF, Myltygashev MP, Berezhnoj AG. Primenenie nejronnyh setej v vybore metoda lecheniya mochekamennoj bolezni [The use of neural networks in the choice of treatment of urolithiasis]. Omskij nauchnyj vestnik [Omsk Scientific bulletin]. 2015; 1 (138): 68-70.

11. Soldatova OP, Semenov VV. Primenenie nejronnyh setej dlya resheniya zadach prognozirovaniya [The use of neural networks to solve prediction problems]. Elektronnyj nauchnyj zhurnal «Issledovano v Rossii» [Electronic scientific journal «Research in Russia»]. 2006; http:// zhurnal.gpi.ru/articles/2006/136.pdf

12. Heaton J. Encog: Library of Interchangeable Machine Learning Models for Java and C. Journal of Machine Learning Research. 2015; 16: 1243-1247.

 

UDC 616.314-089.23:616.314-77

DOI: 10.20969/VSKM.2019.12(3).44-47

PDF download THE IMPACT OF THE SECOND CLINICAL STAGE ON INEFFECTIVE PROSTHETIC TREATMENT IN FULL OVERDENTURE RESTORATION

PANAKHOV NAZIM A., D. Med. Sci., professor of the Department of prosthetic dentistry of Azerbaijan Medical University, Azerbaijan, AZ 1007, Baku, Gasymzade str., 14

BAYRAMOV YUNIS I., Ph. D. in Medicine, assistant of professor of the Department of prosthetic dentistry of Azerbaijan Medical University, Azerbaijan, AZ 1007, Baku, Gasymzade str., 14, e-mail: mic_amu@mail.ru

MUSAYEV EMIN R., Ph. D. in Medicine, assistant of professor of the Department of prosthetic dentistry of Azerbaijan Medical University, Azerbaijan, AZ 1007, Baku, Gasymzade str., 14

Abstract. Aim. Study of the influence of the second clinical stage of denture manufacture on ineffective prosthetic treatment in full overdenture restoration. Material and methods. A retrospective analysis of the results of treatment wasperformed in 1400 patients with complete secondary edentulous at the age of 34–69 years [mean age (56±6,3) years] who had received prosthetic treatment via complete overdenture restoration. Anatomical impressions were made with elastic impression mass (İpeen, Hydrocolor), functional impressions were obtained via crystallizing impression materials (repin, silicone-correction layer impression material). Chewing efficacy evaluation was performed by I.S. Rubinova method in 62 patients using denture for 2 years out of the total number, on the day of prostheses delivery, after 1 month, 12, and 24 months. The data obtained were processed by methods of variation statistics, including calculation of the mean and the error of the mean (M±m). Results and discussion. When analyzing the condition of patients after prosthetics, it was revealed that 58,9% of them had overdenture restoration fixation errors in the process of chewing food, 40,1% had various diseases of the mucous membrane. 39,1% of patients complained of impaired speech, 15% of aesthetic deficiencies and whistles when talking, 27,4% of food penetration under the denture, 10,4% of denture instability in the mouth when consuming liquid food, 28,6% – of nausea and urge to vomit. 25,6% of patients were not using overdenture restorations made for them. The best chewing efficacy indicators were recorded 12 months after the denture was delivered (p˂0,05). However, deterioration in performance was subsequently noted. Conclusion. Thus, in order to prevent complications during prosthetics at the second clinical stage, the pressure on prosthetic bed area applied by the dentist when taking a functional impression with an individual spoon until the impression mass hardens, while thepatient performs various functional movements has to comply with such in overdenture restorations on prosthetic bedsurface. However, the impression obtained with individual spoon was not functional.

Key words: individual spoon, functional impression, prosthetic bed, full overdenture restoration.

For reference: Panakhov NL, Bayramov YuI, Musayev ER. The impact of the second clinical stage on ineffective prosthetic treatment in full overdenture restoration. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 44-47.DOI: 10.20969/VSKM.2019.12(3).44-47.

REFERENCES

1. Nespryad’ko VP, Baranovskij AV, Kisel’ ZF. Osobennosti ortopedicheskiogo lecheniya pacientov s polnym otsutstviem zubov na odnoj iz chelyustej [Features oforthopedic treatment of patients with complete absenceof teeth in one of the jaws]. Sovremennaya stomatologiya [Modern dentistry]. 2014; 1: 81–83.

2. Baradina IN, Gun’ko II, Lobko VA. Adaptaciya k s»emnym zubnym protezam [Adaptation to removable dentures]. Minsk: BelMAPO. 2012; 40 p.

3. Zholudev SE. Osobennosti protezirovaniya polnymi s»emnymi protezami i adaptacii k nim u lic pozhilogo i starcheskogo vozrasta [Features of prosthetics with fullremovable prostheses and adaptation to them in elderlyand senile persons]. Ural’skij medicinskij zhurnal [Ural Medical Journal]. 2012; 8: 31-35.

4. Zholudev SE, Gette SA. Reshenie problemy adaptacii k s»emnym konstrukciyam zubnyh protezov pri polnoj utrate zubov (klinicheskij sluchaj) [Solution of the problemof adaptation to the removable structures of dentureswith the complete loss of teeth (clinical case)]. Problemy stomatologii [Dental problems]. 2016; 12 (3): 46-51. DOI: 10.18481/2077-7566-2016-12-3-46-51

5. Shulyatnikova OA. Optimizaciya ortopedicheskogo etapa lecheniya v kompleksnoj specializirovannoj pomoshchi pacientam s defektami chelyustno-licevoj oblasti [Optimization of the orthopedic treatment in complex specialized care for patients with defects in the maxillofacial area]. Rossijskij stomatologicheskij zhurnal [Russian Dental Journal]. 2016; 20 (2): 38—41.

6. Naumovich SA. Sovremennye aspekty izgotovleniya polnyh s»emnyh protezov [Modern aspects of the fabricating of full denture]. Minsk: BSMU. 2012; 120p.

7. Lobko VA, Pryalkin SV, Troyanovskaya MS. Sposob izgotovleniya polnogo s»emnogo proteza chelyusti [A method of fabricating a complete denture jaw]. Sovremennaya stomatologiya [Modern dentistry]. 2013; 2: 33–37.

8. Johnson T, Wood DJ. Techniques in Complete Denture Technology. Wiley-Blackwell. 2012; 113 p.

9. Hrvoje Kršek, Nikša Dulčić. Functional Impressions in Complete Denture and Overdenture Treatment. Acta Stomatol Croat. 2015; 49 (1): 45–53. DOI: 10.15644/ asc49/1/6

10. Trezubov VN, Shcherbakov AS, Mishnev LM. Ortopedicheskaya stomatologiya; Propedevtika i osnovy chastnogo kursa [Prosthetic dentistry; Propaedeutics and the basics of the private course]. SPb: SpetsLit [SPb: SpecLit]. 2014; 480 p.

 

UDC 616.2-036.22:314.14(571.17)

DOI: 10.20969/VSKM.2019.12(3).47-53

PDF download RESPIRATORY DISEASES IN INDUSTRIAL REGION OF SIBERIA: MORBIDITY ANALYSIS ON THE EXAMPLE OF THE KEMEROVO REGION

KHANIN ARKADIY L., professor, Head of the Department of phthisiopulmonology of Novokuznetsk State Institute for Advanced Physician training – the branch of Russian Medical Academy of Postgraduate Education, Russia, 654005, Novokuznetsk, Stroitely ave., 5, tel/fax 8(3843)45-42-19, e-mail: prof.khanin@yandex.ru

SHABINA OLESYA P., pulmonologist, Russia, 654007, Novokuznetsk, Kuznetskstroevskiy ave., 11, tel/fax 8(3843)99-40-40, e-mail: o.shabina@gm.clinic

VIKTOROVA IRINA B., С. Med. Sci., associate professor of the Department of phthisiopulmonology of Novokuznetsk State Institute for Advanced Physician training – the branch of Russian Medical Academy of Postgraduate Education, Russia, 654005, Novokuznetsk, Stroitely ave., 5, tel/fax 8(3843)45-42-19, e-mail: irinaviktoroff@mail.ru

Abstract. Aim. The aim of the research was to study the incidence of respiratory diseases in the region with highindustrial pollution of the environment (coal, metallurgical, chemical and construction industries) on the example of the Kemerovo region. Material and methods. Publication data and official statistical materials for the years 2015 and 2016 have been applied. Results and discussion. The incidence of respiratory diseases in Kuzbass is 2,4 times higher comparing to injuries, poisoning or other diseases caused by external causes, 5,4 times – diseases of the genitourinary system, 6,5 times – diseases of the musculoskeletal system, 7,25 times – diseases of the circulatory system and 8,5 times – diseases of the digestive system. The incidence of community-acquired pneumonia is higher by 25,9%, the one of bronchial asthma and other respiratory allergies is higher by 40,8%, and the one of chronic obstructive pulmonary disease is 2 times higher than in the Russian Federation. The incidence of tuberculosis, multidrug-resistant tuberculosis, tuberculosis with HIV infection was 2,0; 2,4 and 6,75 times, respectively, higher comparing to national indicators. The incidence of malignant respiratory diseases was 5,7% higher than the mean indicator for the Russian Federation. Conclusion. Respiratory diseases are the leading ones in Kuzbass, which is primarily associated with a high concentration of coal and metallurgical enterprises, creating an unfavorable ecological situation and, accordingly, a high load on the respiratory system of the population living in the region.

Key words: Kemerovo region, respiratory diseases, incidence.

For reference: Khanin AL, Shabina OP, Viktorova IB. Respiratory diseases in industrial region of Siberia: morbidity analysis on the example of the Kemerovo region. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 47-53.DOI: 10.20969/VSKM.2019.12(3).47-53.

REFERENCES

1. Aysanov ZR, Avdeyev SN, Arkhipov VV, et al. Natsional’nyye klinicheskiye rekomendatsii po diagnostike i lecheniyu khronicheskoy obstruktivnoy bolezni legkikh

[National Clinical Guidelines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease]. Pul’monologiya [Pulmonology]. 2017; 27 (1): 13-20. DOL: 10.18093/0869.0189-2017-27-1-13-20.

2. Khanin AL, Chernushenko TI, Kravchenko NI. Problemy bolezney organov dykhaniya i vozmozhnyye puti ikh resheniya na urovne munitsipal’nogo zdravookhraneniya [Problems of respiratory diseases and possible solutions to them at the municipal health care level]. Pul’monologiya [Pulmonology]. 2011; 2: 115-118.

3. Ivanova YeV, Belichenko TN, Chuchalin AG. Zabolevayemost’ i smertnost’ naseleniya trudosposobnogo vozrasta po prichine bolezney organov dykhaniya v 2010-2012 gg [Morbidity and mortality of the working age population due to respiratory diseases in 2010-2012]. Pul’monologiya [Pulmonology]. 2015; 25 (3): 291-297. DOI: 10.18093/0869.0189-2015-25-3-291-297.

4. Welte T. Respiratory epidemiology: ERS monograph [Respiratory epidemiology: ERS monograph]. European Respiratory Society [European Respiratory Society]. 2014; 62-124.

5. Chuchalin AG, Khaltayev NG, Abrosimov VI et al. Otsenka rasprostranennosti respiratornykh simptomov i vozmozhnosti skrininga spirometrii v diagnostike khronicheskikh legochnykh zabolevaniy [Estimation of theprevalence of respiratory symptoms and the possibility of spirometry screening in the diagnosis of chronic lungdiseases]. Pul’monologiya [Pulmonology]. 2010; 2: 56-60.

6. Khanin AL, Chernushenko TI, Morozova GV, et al. Rasprostranennost’ respiratornykh simptomov i vozmozhnosti vyyavleniya khronicheskoy obstruktivnoy bolezni legkikh v shakhterskom gorode Kuzbassa [Prevalenceof respiratory symptoms and the possibility of detecting chronic obstructive pulmonary disease in the mining townof Kuzbass]. Pul’monologiya [Pulmonology]. 2012; 3: 59-62.

7. Kolosov VP, Kurganova OV, et al. Epidemiologicheskiye osobennosti vnebol’nichnykh pnevmoniy v Amurskoy oblasti, problemy i puti ikh resheniya [Epidemiological features of community-acquired pneumonia in the Amur region, problems and ways to solve them]. Byulleten’ fiziologii i patologii dykhaniya [Bulletin of physiology and pathology of respiration]. 2014; 53: 10-17.

8. Vafin AYu, Vizel’ AA, Sherputovskiy VG, et al. Zabolevaniya organov dykhaniya v respublike Tatarstan: mnogoletniy epidemiologicheskiy analiz [Diseases of the respiratory system in the Republic of Tatarstan: a long-term epidemiological analysis]. Vestnik sovremennoy klinicheskoy meditsiny [Bulletin of modern clinical medicine]. 2016; 9 (1): 24-31.

9. Tsarik GN, Shternis TA, Bogomolova NS. Problemy i perspektivy okazaniya meditsinskoy pomoshchi rabotnikam ugledobyvayushchikh predpriyatiy [Problemsand prospects of providing medical assistance toemployees of coal mining enterprises]. Meditsina v Kuzbasse [Medicine in Kuzbass]. 2013; 3: 11-16.

10. Khanin AL, Andreyanova MA, Shutnikova GA. Analiz rasprostranennosti obshchesomaticheskoy i professional’noy patologii u rabochikh ugol’nykh shakht i razrezov shakhterskogo goroda Kuzbassa [Analysis of theprevalence of general somatic and occupational pathologyamong working coal mines and mines of the mining city of Kuzbass]. Vestnik sovremennoy klinicheskoy meditsiny [Bulletin of modern clinical medicine]. 2016; 9 (5): 56-60.

11. Kemerovskaya oblast’ [Kemerovo region]. https:// ru.wikipedia.org/wiki/Kemerovskaya_oblast’

12. Ekonomika Kemerovskoy oblasti [Economy of the Kemerovo region]. https://ru.wikipedia.org/wiki/ Ekonomika_Kemerovskoy_oblasti

13. Kemerovskaya oblast’: Gosudarstvennaya informatsionnaya sistema promyshlennosti [Kemerovo region: State information system of industry]. https://gisp.gov.ru/

regions/3491/

  1. Kemerovskaya oblast’ [Kemerovo region]. http://loi.sscc. ru/bdm/nso/attr/sfo/kemer.htm

  2. Departament monitoringa, analiza i strategicheskogo razvitiya zdravookhraneniya Rossii [Department of monitoring, analysis and strategic development of health care of the Ministry of Health of the Russian Federation]. Zabolevayemost’ vsego naseleniya Rossii v 2016 godu; Sbornik statisticheskikh materialov, I chast’ [The incidence of the total population of Russia in 2016; Collection of statistical materials, Part I]. Moskva: «Tsentral’nyy NII organizatsii i informatizatsii zdravookhraneniya» [Moscow: «Central Research Institute of Organization and Informatization of Healthcare»]. 2017; 140 p.

16. Kaprin AD, Starinskiy VV, Petrova GV. Zlokachestvennyye novoobrazovaniya v Rossii v 2015 godu (zabolevayemost’ i smertnost’) [Malignant neoplasms in Russia in 2015 (morbidity and mortality)]. Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut (MNIOI) imeni P.A. Gertsena – filial FGBU «NMITS radiologii» Minzdrava Rossii [Moscow Research Institute of Oncology (Moscow), PA Herzen – branch of the FSBI «NMITS radiology» of the Ministry of Health of Russia]. 2017; 250 p.

17. Kaprin AD, Starinskiy VV, Petrova GV. Zlokachestvennyye novoobrazovaniya v Rossii v 2016 godu (zabolevayemost’ i smertnost’) [Malignant neoplasms in Russia in 2015 (morbidity and mortality)]. Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut (MNIOI) imeni P.A. Gertsena – filial FGBU «NMITS radiologii» Minzdrava Rossii [Moscow Research Institute of Oncology (Moscow), PA Herzen – branch of the FSBI «NMITS radiology» of the Ministry of Health of Russia]. 2018; 250 p.

18. Epidemicheskaya situatsiya po tuberkulezu v Rossii: Analiticheskiye materialy po tuberkulezu [Epidemic situation of tuberculosis in Russia: Analytical materials on tuberculosis]. http://mednet.ru/ru/czentr-monitoringa-tuberkuleza/produkcziya-czentra/analiticheskie-obzory.html

 

UDC 340.6:611.717.1

DOI: 10.20969/VSKM.2019.12(3).53-56

PDF download GENDER IDENTIFICATION BY INDIVIDUAL BLADE BONE PARAMETERS

CHERTOVSKY ANDREY A., ORCID ID: orcid.org/ 0000-0003-1777-1752; C. Med. Sci., forensic doctor of Bureau of Forensic Medical Examination of the Department of Public Health of Moscow, Russia, 115516, Moscow, Tarny proezd, 3, e-mail: traumfilipp@mail.ru

TUCHIK EVGENIY S., ORCID ID: 0000-0003-4330-2327; D. Med. Sci., professor of the Department of forensic medicine of Russian National Research Medical University named after N.I. Pirogov, Russia, 117997, Moscow, Ostrovityanin str., 1, e-mail: rsmu@rsmu.ru

Abstract. Aim. The aim of the study was to determine blade bone individual parameters significant for gender identification applying blade bone morphometric study and to develop formulas that allow reliable gender determination using statistical methods. Material and methods. The study was based on the data from 108 acts (conclusions) of corpse forensic investigations and morphometric measurements of the blades obtained from them. Osteometric and morphological study methods, as well as mathematical method using applied programs for data statistical processing have been applied. Results and discussion. Certain blade parameters and the relationship of their absolute values with the gender have been studied. The most significant morphometric indicators showing the strongest correlation and accuracy were used to build the formulas, which allow determining the gender of a person with the highest accuracy and simplicity by using only this bone. Correction factors were calculated by statistical methods. Conclusion. The developed method of gender determination, that has a mathematical expression by means of a specific formula, provides extensive identification capabilities in the study of skeletal and strongly burned corpses of unknown persons. Simplicity of the practical application and proposed problem solving algorithm, minor cost of morphometric parameter determination allows significant reduction of the number of manipulations through targeted measurements, which makes it available at any stage of forensic medical corpse examination.

Key words: osteometry, blade bone, identification, statistics, gender.

For reference: Chertovsky AA, Tuchik ES. Gender identification by individual blade bone parameters. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 53-56. DOI: 10.20969/VSKM.2019.12(3).53-56.

REFERENCES

1. Barinov EKh, Shcherbakov VV, Fedulova MV, Goncharova NN. Identifikatsiya lichnosti pri chrezvychaynykhproisshestviyakh s massovymi chelovecheskimi zhertvami [Identification of the person in case of emergency with mass human victims]. Kirov-Moskva: KOGUZ «Meditsinskiy informatsionno-analiticheskiy tsentr» [Kirov-Moscow: KOGUZ Medical Information Analytical Center]. 2008; 235 p.

2. Osipenkova-Vichtomova TK. Gistomorfologicheskaya ekspertiza kostey [Histomorphological examination of bones]. Moskva: «Meditsina» [Moscow: «Medicine»]. 2009; 152 p.

3. Alekseev VP. Osteometriya; Metodika antropologicheskikh issledovaniy [Osteometry; Methods of anthropological research]. Moskva: «Nauka» [Moscow: «Science»]. 1966; 251 p.

4. Alekseev VP, Debets GF. Kraniometriya; Metodika antropologicheskikh issledovaniy [Craniometry; Methods of anthropological research]. Moskva: «Nauka» [Moscow: «Science»]. 1964; 128 p.

5. Zel’tser A. Prichiny i formy proyavleniya uskorennogo rosta detey [Causes and forms of manifestation of accelerated growth of children]. Moskva: «Meditsina» [Moscow: «Medicine»]. 1968; 235 p.

6. Markosyan AA. Voprosy vozrastnoy fiziologii [Questions of age physiology]. Moskva: «Prosveshchenie» [Moscow: «Enlightenment»]. 1974; 223 p.

7. Miklashevskaya NN. Rost i razvitie rebenka [Growth and development of the child]. Moskva: Izdatel’stvo Moskovskogo universiteta [Moscow: Publishing House of Moscow University]. 1973; 220 p.

8. Roginskiy YaYa, Levin MG. Osnovy antropologii [Basics of anthropology]. Moskva: Izdatel’stvo Moskovskogo universiteta [Moscow: Publishing House of Moscow University]. 1955; 502 p.

9. Zvyagin, VN, Zamyatina AO, Galitskaya OI. Diagnostikamassivnosti skeleta i somatotipa cheloveka po kostyamkisti [Diagnosis of the massiveness of the skeleton and human somatotype on the bones of the hand]. Sudebno-meditsinskaya ekspertiza [Forensic medical examination]. 2003; 6: 19-25.

10. Pigolkin YuI, Fedulova MV, Zolotenkova GV. Opredelenie vozrasta cheloveka po kostnoy tkani [Determination of human age by bone tissue]. Sudebno-meditsinskaya ekspertiza [Forensic medical examination]. 2012; 1: 49-51.

11. Naynis IV. Identifikatsiya lichnosti po proksimal’nym kostyam konechnostey [Identification of the person by the proximal bones of the limbs]. Vil’nyus: Izdatel’stvo «Mintis» [Vilnius: Minthis Publishing House]. 1972; 158 p.

  1. Koshelev LA. O polovom dimorfizme lopatok [On sexual dimorphism of the blades]. Sudebno-meditsinskaya ekspertiza [Forensic medical examination].1971; 4: 22-23.

  2. Laptev ZL. Opredelenie pola i dliny tela po parametram lopatok [Determination of sex and body length by the parameters of the blades]. Sudebno-meditsinskaya ekspertiza [Forensic medical examination]. 1978; 3: 7-11.

  3. Gurova NI. Vozrastnaya morfologiya grudnoy kletki cheloveka [Age morphology of the human thorax]. Moskva: «Prosveshchenie» [Moscow: «Enlightenment»]. 1965; 216 p.

 

UDC 616.153.915-008.61-08

DOI: 10.20969/VSKM.2019.12(3).56-59

PDF download NEW APPROACHES TO PREVENT AND TREAT INCRESED SERUM LIPIDS

SHAH MURAD, MBBS, M. Phil, professor, the Head of the Department of pharmacology of Islamabad Medical & Dental College and Dr. Akbar Niazi Teaching Hospital, Wadi-ul-Ilm Main Murree Road, Bharakahu, Islamabad, Pakistan, tel. +92-314-224-34-15, e-mail: shahhmurad@gmail.com

MASTOI ISHAQ M., PRO, Pakistan Agricultural Research Council, Park Road, Pakistan, 44000, Islamabad

ARAIN ABDUL QUDOOS, associate professor of Pharmacology at HBS Medical College, Lehtarar Road, Pakistan, IslamabadSHAFIQUE ADNAN, Cl pharmacist at MCC Pharmacy, Pakistan, Islamabad

ASLAM HINA, associate professor, Pharmacology, Islamabad Medical & Dental College and Dr. Akbar Niazi Teaching Hospital, Wadi-ul-Ilm Main Murree Road, Bharakahu, Pakistan, Islamabad

NIAZI AKBAR KHAN, MBBS, venerologist, the Chairman of Islamabad Medical & Dental College and Dr. Akbar Niazi Teaching Hospital, Islamabad, Pakistan, Wadi-ul-Ilm Main Murree Road, Bharakahu, Islamabad, tel. +92-314-224-34-15

Abstract. Inflammation triggered by oxidative stress is the cause of much, perhaps even most, chronic human disease including human aging. The oxidative stress originates mainly in mitochondria from reactive oxygen and reactive nitrogen species (ROS/RNS) and can be identified in most of the key steps in the pathophysiology of atherosclerosis and the consequential clinical manifestations of cardiovascular disease. In addition to the formation of atherosclerosis, it involves lipid metabolism, plaque rupture, thrombosis, myocardial injury, apoptosis, fibrosis and failure. The recognition of the critical importance of oxidative stress has led to the enthusiastic use of antioxidants in the treatment and prevention of heart disease, but the results of prospective, randomized clinical trials have been overall disappointing. Conventional hypolipidemic drugs have unwanted effects. Herbal therapy for Hyperlipidemia is getting attention due to their less frequent side effects. Aim. In this study we have compared hypolipidemic effects of Fenofibrate 40 mg with Nigella sativa. Material and methods. Seventy five hyperlipidemic patients from National Hospital Lahore were enrolled for study. After getting consent all patients were divided in three groups comprising 25 patients in each group. Group 1 was on Nigella sativa, group 2 was on Gemfibrozil and third group was on placebo therapy. They were advised to take drugs for two months. After completion of study pretreatment and post treatment values of low density lipoproteins cholesterol were analyzed statistically.Results and discussion. In Nigella sativa group low density lipoproteins cholesterol decreased from (191,14±3,45) mg/ dl to (159,40±2,98) mg/dl, means 31,7 mg/dl low density lipoproteins reduction was observed when compared with placebo group. In Fenofibrate group of patients’ low density lipoproteins cholesterol decreased from (197,77±3,91) mg/dl to (159,62±2,20) mg/dl, means low density lipoproteins reduction in mean values was 38,2 mg/dl, when compared with placebo group. These changes are highly significant with p-values of <0,001. Conclusion. We concluded from this study that herbal medicine Nigella sativa is as effective as traditionally used hypolipidemic drug Fenofibrate.

Key words: oxidative stress, fibrates, serum lipids, Nigella sativa.

For reference: Shah M, Mastoi IM, Arain AQ, Shafique A, Aslam H, Niazi AKh. New approaches to prevent and treat increased serum lipids. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 56-59. DOI: 10.20969/ VSKM.2019.12(3).56-59.

REFERENCES

  1. Morihana HH, Kostapanos MS, Liamis GL, Milionis HJ, Elisaf MS. Fibrates are used in all hyperlipidemic patients but be aware about its SEs. Lipid Pharmacol. 2014; 8: 112-131.

  2. Suwa L, Wolfe K, Wu X, Liu RH. Antioxidant activity of Nigela sativa. J Food Chem. 2013; 5: 122-128.

  3. Maqbool YT, Uddin SN. Kalwanji affects plasma lipids: How? Ir J Lipids. 2014; 4 (4): 222-227.

  4. Mahmud FR, Mahmud ZA, Bachar SC, Qais N. Antihyperlipidemic activity of herbal agent NS. Pharm Exp Med. 2014; 11: 267-268.

  5. Fateh MA, Ahmed KA, Muniandy S, Ismail IS. Role of Nε-(carboxymethyl) lysine in the development of ischemic heart disease in type 2 diabetes mellitus. J Clin Biochem Nutr. 2013; 43: 197-200.

  6. Moraka L, Scharnagl H, Nauck M, Wieland H, Marz W. Fenofibrates are safe drugs to treat dyslipidemia? Clin Chem Lab Med. 2014; 40: 526-528.

  7. Foorah SK, Asaduzzaman Kh, Chen H-Ch, Mousumi T, Zhang D-Zh. How do Fenofibrate lower blood lipids in human population: L MOA. J Ir Med. 2014; 10 (5): 326-327.

  8. Jahad KI, Assayed ME. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Immunopharmacol Immunotoxicol. 2014; 34: 484-485.

  9. Maqawat K, Yusuf M, Begum J, Hoque N, Chowdhury JU. Nigella sativa for asthma and lipids treatment. J Med Sc. 2013; 12 (7): 334-339.

10. Gurahav UT, Genwich UY, Oram JF, Lawn RM. ABCA1.Coronary artery disease is major cause of mortality inthe world. Journal of Lipid research. 2014; 44 (8): 1307-1309.

11. Lapella D, Okamoto H, Kamatani N. Dyslipidemia: Successful treatment with Fenofibrate. Annals of the rheumatic diseases. 2013; 67 (13): 1509-1510.

12. Khuve J, Ali S, Al-Elyani F. CAD is big problem but its solution is easy, just prevent hyperlipidemia. J Sci Med. 2013; 25: 1239-1241.

13. Furkhan HY, Hossain MA, Tsujita M, Gonzalez FJ, Yokoyama S. How heart diseases are affecting human population? Journal of cardiovascular pharmacology. 2013; 51 (8): 1258-1259.

14. Moghaba GT, Abdel-Aal ESM, Attia RS. Normal lipids: Healthy heart. Alex Sci Exch. 2013; 15: 583-590.

15. Summat BS, Zeggwagh NA, Moufid A, Khaldi A, Michel JB, Eddouks M. Cardiovascular effects of Nigella sativa aqueous extract. Circulation. 2013; 9 (1): 134-136.

16. Malaqa FG, Han SH, Quon MJ, Koh KK. Use of Nigella sativa in Hyperlipidemia. Clinical Pharmacology. 2013; 47 (7): 1170-1172.

17. Gurfatv JH, Mohalee KI, Dehkordi FR, Kamkhah AF. Antihyperlipidemic effects of Nigella sativa seed extract in patients with primary Hyperlipidemia. Fundamental and Clinical Pharmacology. 2014; 84 (7): 1302-1303.

18. Sangatt U, Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Strandberg T, Tonstad S, Gylling H. Fibrates for familial hypersholesterolemia. Cochrane Database of Systematic Reviews. 2014; 10 (2): 222-224.

19. Beghanah JJ, Dellavalle RP, Nicholas MK, Schilling LM. Role of Fibrates in hypercholesterolemia. American journal of therapeutics. 2014; 112 (1): 403-408.

20. Turtesov T, Dasgupta S, Roy A, Jana M, Hartley DM, Pahan K. Gemfibrozil reduces risk of coronary artery disease. Lipid Pharmacology. 2014; 73 (1): 1018-1023.

21. Jatoi KA, Ghulam MM, Abdul QA. MOA of fibrates. As Jou Med Health Sc. 2012; 2 (7): 110-117.

22. Mastoi SM, Yusafzai KN, Shoro GA, Lakho RL. Dyslipidemia and its cure. AJMS. 2013; 7 (4): 334-337.

 

PRESS RELEASE (RUSSIAN ONLY)

 

ORGANIZATION OF HEALTHCARE

UDC 614.2:616.1/.9-082

DOI: 10.20969/VSKM.2019.12(3).61-66

PDF download ASSESSMENT OF HEALTH CENTER RISKS, RELATED TO MEDICAL CARE DELIVERY IN THERAPEUTIC DEPARTMENTS

KHARISOV ALSIM M., C. Med. Sci., Head of the branch No 3 of Military Clinical Hospital No 3 named after A.A. Vishnevsky, Russia, 143000, Moscow region, Odintsovo, Marshal Biryusov str., 1, tel. 8-985-826-29-72, e-mail: amkharisov1968@mail.ru

BERSENEVA EVGENIA A., D. Med. Sci., professor, Head of the Center of the higher and additional professional education of National Research Institute of Public Health named after N.A. Semashko, Russia, 105064, Moscow, Vorontsovo Pole str., 12, bld. 1, tel. 8-916-216-84-59, e-mail: eaberseneva@gmail.com

BEREZNIKOV ALEXEY V., D. Med. Sci., associate professor, Head of the Directorate of medical expertise of LLC «AlfaStrakhovanie-OMS», Russia, 115162, Moscow, Shabolovka str., 31, bld. 11, tel. 8-964-799-10-22, e-mail: avbereznikov@mail.ru

SHKITIN SERGEY O., Head of the Department of planning and expertise control of the Directorate of medical expertise of LLC «AlfaStrakhovanie-OMS», Russia, 115162, Moscow, Shabolovka str., 31, bld. 11, tel. 8-903-963-39-32, e-mail: ishkitin@gmail.com

SKIBA YAROSLAV В., C. Med. Sci., senior resident of the Department of neurology of Мilitary Clinical Hospital No 3 named after A.A. Vishnevsky, Russia, 143000, Moscow region, Odintsovo, Marshal Biryusov str., 1, tel. 8-965-753-85-53, e-mail: yaver-99@mail.ru

KLIMOV YURI A., C. Med. Sci., chief physician of Podolsk Children’s City Hospital, chief freelance specialist for medical rehabilitation, Russia, 142110, Moscow region, Podolsk, Kirov str., 38, tel. 8-4967-54-48-87, e-mail: pdgb-podolsk@mail.ru 

Abstract. Aim. The aim of the study was to develop a method for assessment of the risks related to medical care delivery to patients in therapeutic departments of medical centers, to test the method and to evaluate the results of its application. Material and methods. The subject of the study was the risks of a medical organization related to medical care delivery to patients in therapeutic departments. The object of the study was the activity of the therapeutic departments of a multidispecialty medical center. The study was conducted applying the following general research and special methods: logical method, analysis and synthesis, abstraction, analogy-based inference method, and systematic approach. Results and discussion. Reputational, financial and legal risks were outlined. The models of their implementation were proposed. Mandatory conditions for their implementation and the main risk forming process was highlighted. A method including evaluation of the stages of medical care business process, the outcomes of medical care and business process control outlines was developed. Conclusion. The applicable risk assessment method for a medical organization related to medical care delivery to patients in therapeutic departments can be applied to manage the quality of medical care for the purpose of reputational, financial and legal risk leveling.

Key words: medical center risk assessment, medical care quality.

For reference: Kharisov AM, Berseneva EA, Bereznikov AV, Shkitin SO, Skiba YaB, Klimov YuA. Assessment of health center risks, related to medical care delivery in therapeutic departments. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 61-66. DOI: 10.20969/VSKM.2019.12(3).61-66.

REFERENCES

1. Bereznikov AV, Konev VP, Onufriychuk YuO et al. Jekspertnaja dejatel’nost’ v objazatel’nom medicinskom strahovanii: prakticheskoe posobie [Expert activity in compulsory medical insurance: practical manual]. Moskva: Infra-M [Moscow: Infra-M]. 2016; 184 p.

2. Ivanov IV, Sharikadze DT, Berseneva EA, et al. Metodicheskie podhody k formirovaniyu risk-orientirovannoj modeli kontrol’no-nadzornoj deyatel’nosti v sfere zdravoohraneniya [Methodical approaches to the formation of a risk-oriented model of control and supervisory activities in the field of health]. Vestnik Roszdravnadzora [Bulletin of Roszdravnadzor]. 2017; 1: 34-36.

3. Federal’naya sluzhba po nadzoru v sfere zdravoohranenija [Federal Service for Supervision of Health]. Predlozhenija (prakticheskie rekomendacii) po organizacii vnutrennego kontrolja kachestva i bezopasnosti medicinskoj dejatel’nosti v medicinskoj organizacii (stacionare) [Suggestions (practical recommendations) on the organization of internal quality control and safety of medical activities in the medical organization (hospital)]. Moskva: Tsentr monitoringa i kliniko-ekonomicheskoy ekspertizy [Moscow: Center for Monitoring and Clinical and Economic Expertise]. 2015; 116 p.

4. Mezhgosudarstvennyj standart GOST ISO 9000-2011 «Sistemy menedzhmenta kachestva» ot 1 yanvarya 2013 [Interstate standard GOST ISO 9000-2011 «Quality management systems from January 1, 2013]. 2013.

5. Federal’nyj zakon ot 21 noyabrya 2011 goda No 323-FZ «Ob osnovah ohrany zdorov’ya grazhdan v Rossijskoj Federacii» [Federal law of November 21, 2011 No 323-FZ «On Fundamentals of health protection of citizens in the Russian Federation»]. 2011.

6. Gracheva TYu, Berseneva EA, Kaminskaya ON, et al. Yuridicheskie osnovy deyatel’nosti vracha: uchebnoe posobie [Legal basis of the doctor’s activity: Textbook]. Kemerovo: KemGU [Kemerovo: KemSU]. 2017; 343 p.

7. Porjadok organizacii i provedenija kontrolja ob’emov, srokov, kachestva i uslovij predostavlenija medicinskoj pomoshhi po objazatel’nomu medicinskomu strahovaniju, utverzhdennomu prikazom Federal’nogo fonda objazatel’nogo medicinskogo strahovanija ot 01.12.2010 No 230 [The procedure for the organization and monitoring of volumes, terms, quality and conditions for the provision of medical assistance for compulsory health insurance, approved by the Order of the Federal Fund of Mandatory Medical Insurance No 230 of December 1, 2010]. 2010.

8. Pravila obyazatel’nogo medicinskogo strahovaniya, utverzhdennogo Prikazom Ministerstva zdravoohraneniya i social’nogo razvitiya RF ot 28 fevralya 2011 goda No 158n [The rules of compulsory medical insurance, approved by the Order of the Ministry of Health and Social Development of the Russian Federation of February 28, 2011 No 158n]. 2011.

9. Federal’nyj zakon ot 29 noyabrya 2010 goda No 326-FZ «Ob obyazatel’nom medicinskom strahovanii v Rossijskoj Federacii» [Federal Law of November 29, 2010 No. 326-FZ «On Compulsory Health Insurance in the Russian Federation»]. 2010.

10. Bereznikov AV, Berseneva EA, Shkitin SO. Ekspertiza kachestva medicinskoj pomoshchi: uchebnoe posobie [Examination of the quality of medical care: Training manual]. Moskva: OOO «Svetlica» [Moscow: Svetlitz Ltd]. 2018; 176 p.

11. Ukaz Prezidenta Rossijskoj Federacii ot 31 dekabrya 2015 goda No 683 «O strategii nacional’noj bezopasnosti Rossijskoj Federacii» [Decree of the President of the Russian Federation of December 31, 2015 No 683 «On the National Security Strategy of the Russian Federation»]. 2015.

 

EXPERIMENTAL STUDIES – TO CLINICAL MEDICINE

UDC 616.72-002-092.9-085.275.3

DOI: 10.20969/VSKM.2019.12(3).67-72

PDF download THE EFFECT OF SODIUM CHONDROITIN SULFATE AND BETAMETHASONE ON ARTICULAR CARTILAGE REMODELING IN EXPERIMENTAL OSTEOARTHRITIS

KABALYK MAXIM A., C. Med. Sci., associate professor of Institute of internal medicine and instrumental diagnostics of Pacific State Medical University, Russia, 690002, Vladivostok, Ostryakov ave., 2, tel. 8(964)439-79-27, e-mail: maxi_maxim@mail.ru

NEVZOROVA VERA A., D. Med. Sci, professor, the Head of the Institute of internal medicine and instrumental diagnostics of Pacific State Medical University, Russia, 690002, Vladivostok, Ostryakov ave., 2, tel. 8(914)790-48-52, e-mail: nevzorova@inbox.ru

TSYGANKOV MIKHAIL A., VI year student, general medicine specialty, Pacific State Medical University, Russia, 69002, Vladivostok, Ostryakov ave., 2

DUBOV VITALY S., VI year student, general medicine specialty, Pacific State Medical University, Russia, 69002, Vladivostok, Ostryakov ave., 2

Abstract. Aim. The aim of the study was to evaluate the effect of intra-articular chondroitin sulfate injection on the expression of matrix metalloprteinase-9 and vascular endothelial growth factor in osteoarthritis animal model. Material and methods. The study was conducted on 18 outbred guinea pigs. In control and experimental groups, the knee joints of the hind legs were mechanically modeled by closed scarification injury application with a sterile needle. In the control group, physiological saline sodium chloride was injected into the affected joints. The animals in the experimental groups were administered intra-articular sodium chondroitin sulfate and betamethasone. The samples of the joints were taken after 4, 6 and 8 weeks. Immunohistochemical method with peroxidase reaction was used to identify tissue expression of vascular endothelial growth factor and matrix metalloproteinase-9. Upon completion of the study specimen evaluation was carried out. Immunohistochemical reaction quantitative evaluation was determined by the value of tissue expression. Results and discussion. Evaluation of tissue expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in damaged joints showed that on the 30th day of the experiment, animals receiving betamethasone showed a statistically significant decrease in VEGF tissue expression and an increase in MMP-9 expression comparing to control. Significantly higher MMP-9 concentrations in articular cartilage compared to the control were seen in the group of animals that received intra-articular chondroitin sulphate. On the 45th day of the experiment there was a statistically significant decrease in immunohistochemical reaction of articular cartilage on VEGF and an increase in MMP-9 concentration in the group that received betamethasone. On the 60th day of betamethasone intra-articular administration, significantly lower VEGF tissue expression and significantly higher MMP-9 expression comparing to the control group was observed. In the group of animals that received chondroitin sulfate, significantly lower levels of VEGF and MMP-9 expression comparing to the control were recorded. The results of the study showed that intraarticular chondroitin sulfate injection in animals with experimental osteoarthritis blocks VEGF angiogenic factor activation in articular cartilage throughout the experiment. Conclusion. In animal osteoarthritis model it was revealed that intraarticular chondroitin sulfate injections lead to vascular endothelial growth factor and matrix metalloproteinase 9 expression inhibitions, which indicates the chondroprotective potential.

Key words: osteoarthritis, chondroitin sulfate, betamethasone, metalloproteinase, growth factor.

For reference: Kabalyk MA, Nevzorova VA, Tsygankov MA, Dubov VS. The effect of sodium chondroitin sulfate and betamethasone on articular cartilage remodeling in experimental osteoarthritis. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 67-72. DOI: 10.20969/VSKM.2019.12(3) 67-72.

REFERENCES

1. Nagai T, Sato M, Kobayashi M, Yokoyama M, Tani Y, Mochida J. Bevacizumab, an anti-vascular endothelial growth factor antibody, inhibits osteoarthritis. Arthritis Res Ther. 2014; 16 (5): 427. DOI: 10.1186/s13075-014-0427-y.

2. Zeng GQ, Chen AB, Li W, Song JH, Gao CY. High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis. Genet Mol Res. 2015; 14 (4): 14811-14822. DOI: 10.4238/2015. November.18.46.

3. Kim HR, Lee JH, Kim KW, Kim BM, Lee SH. The relationship between synovial fluid VEGF and serum leptin with ultrasonographic findings in knee osteoarthritis. Int J Rheum Dis. 2016; 19 (3): 233-240. DOI: 10.1111/1756-185X.12486.

4. Tanaka E, Aoyama J, Miyauchi M, Takata T, Hanaoka K, Iwabe T, Tanne K. Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis. Histochem Cell Biol. 2005; 123 (3): 275-281.

5. Wang QY, Dai J, Kuang B, Zhang J, Yu SB, Duan YZ, Wang MQ. Osteochondral angiogenesis in rat mandibular condyles with osteoarthritis-like changes. Arch Oral Biol. 2012; 57 (6): 620-629. DOI: 10.1016/j. archoralbio.2011.12.006.

6. Lipari L, Gerbino A. Expression of gelatinases (MMP-2, MMP-9) in human articular cartilage. Int J Immunopathol Pharmacol. 2013; 26 (3): 817-823.

7. Linares PM, Chaparro M, Algaba A, Román M, Moreno Arza I, Abad Santos F, Ochoa D, Guerra I, Bermejo F, Gisbert JP. Effect of Chondroitin Sulphate on ProInflammatory Mediators and Disease Activity in Patients with Inflammatory Bowel Disease. Digestion. 2015; 92 (4): 203-210. DOI: 10.1159/000439522.

8. Lambert C, Mathy-Hartert M, Dubuc JE, Montell E, Vergés J, Munaut C, Noël A, Henrotin Y. Characterizationof synovial angiogenesis in osteoarthritis patients and itsmodulation by chondroitin sulfate. Arthritis Res Ther. 2012; 14 (2): R58. DOI: 10.1186/ar3771.

9. Campo GM, Avenoso A, Campo S, D’Ascola A, Ferlazzo AM, Samà D, Calatroni A. Purified human chondroitin-4-sulfate reduced MMP/TIMP imbalance induced by iron plus ascorbate in human fibroblast cultures. Cell Biol Int. 2006; 30 (1): 21-30.

10. Scotece M, Conde J, Abella V, López V, Francisco V, Ruiz C, Campos V, Lago F, Gomez R, Pino J, Gualillo O. Oleocanthal Inhibits Catabolic and Inflammatory Mediators in LPS-Activated Human Primary Osteoarthritis (OA) Chondrocytes Through MAPKs/NF-κB Pathways. Cell Physiol Biochem. 2018; 49 (6): 2414-2426. DOI: 10.1159/000493840.

11. Xia B, Di Chen, Zhang J, Hu S, Jin H, Tong P. Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int. 2014; 95 (6): 495-505. DOI: 10.1007/s00223-014-9917-9.

12. Xue M, McKelvey K, Shen K, Minhas N, March L, Park SY, Jackson CJ. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford). 2014; 53 (12): 2270-2279. DOI: 10.1093/rheumatology/keu254.

13. Wang Y, Xu J, Zhang X, Wang C, Huang Y, Dai K, Zhang X. TNF-α-induced LRG1 promotes angiogenesis and mesen-chymal stem cell migration in the subchondral bone duringosteoarthritis. Cell Death Dis. 2017; 8 (3): e2715. DOI: 10.1038/cddis.2017.129.

14. Noh KC, Park SH, Yang CJ, Lee GW, Kim MK, Kang YH. Involvement of synovial matrix degradation and angiogenesis in oxidative stress-exposed degenerative rotator cuff tears with osteoarthritis. J Shoulder Elbow Surg. 2018; 27 (1): 141-150. DOI: 10.1016/j.jse.2017.08.007.

15. Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 2012; 8 (7): 390-398. DOI: 10.1038/ nrrheum.2012.80.].

16. Sandya S, Sudhakaran PR. Effect of glycosaminoglycans on matrix metalloproteinases in type II collagen-induced experimental arthritis. Exp Biol Med (Maywood). 2007; 232 (5): 629-637.

 

CLINICAL CASE

UDC 616.24-022.7-085.281.9-06 

DOI: 10.20969/VSKM.2019.12(3).73-77

PDF download LONG-TERM FEVER AS A MANIFESTATION OF DRUG INTOLERANCE IN PATIENTS WITH NONTUBERCULOUS PULMONARY MYCOBACTERIOSIS (clinical case)

DEGTYAREVA SVETLANA A., ORCID ID: 0000-0002-4541-056X; C. Med. Sci., senior researcher of the Department of tuberculosis differential diagnosis of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: bonita.lana@mail.ru

SHMELEV EVGENIY I., professor, Honored scientist of the Russian Federation, Head of the Department of tuberculosis differential diagnosis of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-08, e-mail: ishmelev@mail.ru

STEPANYAN IGOR E., D. Med. Sci., professor, Honored doctor of the Russian Federation, leading researcher of the Department of tuberculosis differential diagnosis of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: drstepanyan@mail.ru

VLADIMIROVA ELENA B., C. Med. Sci., researcher of the Department of tuberculosis differential diagnosis of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: velebor@mail.ru

KOVALEVSKAYA MARINA N., C. Med. Sci., researcher of the Department of tuberculosis differential diagnosis of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: ya.kovmar60-dom@ya.ru

KASIMTSEVA SVETLANA A., C. Med. Sci., researcher of the Department of tuberculosis differential diagnosis of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-31, e-mail: skasimtseva@mail.ru

HERGERT VLADISLAV YА., professor, Head of the Department of immunology of Central Tuberculosis Research Institute, Russia, 107564, Moscow, Yauzskaya alley, 2, tel. +7(499)785-90-72, e-mail:hergertv@mail.ru

Abstract. A clinical case of a 40-year-old patient with non-tuberculosis lung mycobacteriosis and chronic obstructive bronchitis with bronchiectasis is described. She has been receiving etiotropic chemotherapy for a year, taking intoaccount the sensitivity of the microorganism (M. avium). This led to side effect development presenting by a long lasting fever (three months), which required drug cancelling. A second attempt of prescribing antimicrobial therapy was unsuccessful. Patient monitoring continues at present. Aim. The aim of the study was to demonstrate the manifestationsof drug intolerance in a patient with non-tuberculosis mycobacteriosis with long-term medication. Material and methods.Lung mycobacteriosis diagnosis and treatment was performed in 40 year old patient. Physical examination, blood test, respiratory function evaluation, chest computed tomography and microbiological sputum examination were performed.Results and discussion. Long lasting fever developed as a result of long-term antimicrobial therapy, and this requiredtreatment cancellation in a patient with M. avium lung mycobacteriosis. Conclusion. The presented case demonstratesthe complexity of the long-term continuous non-tuberculosis mycobacteriosis treatment. Antibacterial therapy was canceled due to drug disease manifestations development.

Key words: lung mycobacteriosis, drug intolerance, chemotherapy, diagnostics, drug fever.

For reference: Degtyareva SA, Shmelev EI, Stepanyan IE, Vladimirova EB, Kovalevskaya MN, Kasimtseva SA., Hergert V.Ya. Long-term fever as a manifestation of drug intolerance in patients with nontuberculous pulmonary mycobacteriosis (clinical case). The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 73-77. DOI: 10.20969/ VSKM.2019.12(3).73-77.

REFERENCES

1. Guntupova LD, Borisov SE, Makarova MV, Khachatur’yants EN. Mikobakteriozy organov dykhaniya: epidemiologiya, mikrobiologicheskie i klinicheskie aspekty diagnostiki [Mycobacterioses of the respiratory organs: epidemiology, microbiological and clinical aspects of diagnosis]. Epidemiologiya i infektsionnye bolezni [Epidemiology and infectious diseases]. 2012; 2: 8–14.

2. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley ChL, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007; 175 (4): 367–416.

3. Andréjak C, Nielsen R, Thomsen VO, Duhaut P, Sorensen HT, Thomsen RW. Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculosis mycobacteriosis. 2013; 68 (3): 256–262.

4. Otten TF. Mikobakterioz [Mycobacteriosis]. Moskva: Binom [Moscow: Binom]. 2014: 3 (2): 349–365.

5. Demko IV. Likhoradka neyasnogo geneza [Fever of not clear genesis]. Vestnik Klinicheskoy bolnitsy [Bulletin of the Clinical Hospital]. 2009; 3 (4): 11-14.

6. Ergeshov AE, Shmelev EI, Kovalevskaya MN, Larionova LE, Chernousova LN. Netuberkuleznye mikobakterii u patsientov s zabolevaniyami organov dykhaniya (klinikolaboratornoe issledovanie) [Non-tuberculous mycobacteria in patients with respiratory diseases (clinical and laboratory research)]. Pulmonologiya [Pulmonology]. 2016; 26 (3): 303-308.

7. Ergeshov AE, Shmelev EI, Kovalevskaya MN, Karpina NL, Larionova LE, Chernousova LN. Mikobakteriozy v praktike vrachey pulmonologov i ftiziatrov [Mycobacterioses in the practice of pulmonologists and phthisiatricians]. Tuberkulez i bolezni legkih [Tuberculosis and lung diseases]. 2016; 94 (9): 39-43.

8. Dvoretsky LI. Likhoradka neyasnogo geneza: vsegda li vozmozhna rasshifrovka? [Fever of not clear genesis. Is decoding always possible?]. Trudnyy patsient [Difficult patient]. 2015; 13 (3): 5-10.

 

UDC 616.728.48-001-089.844

DOI: 10.20969/VSKM.2019.12(3).78-82

PDF download SURGICAL TREATMENT OF THE LEAK OF DISTAL TIBIOFIBULAR SYNDESMOSIS AFTER ANKLE FRACTURE (clinical case)

MIKHAILOV SERGEY V., ORCID ID: 0000-0002-3738-0639; C. Med. Sci., assistant of professor of the Department of military traumatology and orthopedics of Kirov Military Medical Academy, Russia, 194044, St. Petersburg, Botkin str., 13, tel. +7-911-004-68-04, e-mail: msv06@mail.ru

KHOMINETS VLADIMIR V., ORCID ID: 0000-0002-7000-6614; D. Med. Sci., professor, Head of the Department of military traumatology and orthopedics of Kirov Military Medical Academy, Russia, 194044, St. Petersburg, Botkin str., 13, tel. +7-921-941-64-16, e-mail: Khominets_62@mail.ru

SHAKUN DMITRY A., ORCID ID: 0000-0002-2723-3707; C. Med. Sci., teaching faculty of the Department of military traumatology and orthopedics of Kirov Military Medical Academy, Russia, 194044, St. Petersburg, Botkin str., 13, tel. +7-911-903-42-70, e-mail: dshakun72@gmail.ru

SHCHUKIN ALEXEY V., ORCID ID: 0000-0002-3423-8367; C. Med. Sci., Head of the Department of Clinic of military traumatology and orthopedics of Kirov Military Medical Academy, Russia, 194044, St. Petersburg, Botkin str., 13, tel. + 7-911-939-60-44, e-mail: ossa.76mail.ru

FOOS IVAN V., ORCID ID: 0000-0002-7845-2133; Head of the Department of Clinic of military traumatology and orthopedics of Kirov Military Medical Academy, Russia, 194044, St. Petersburg, Botkin str., 13,
tel. + 7-905-224-62-97, e-mail: foosiv@mail.ru

KOMAROV ARTEM V., ORCID ID: 0000-0002-8260-0311; chief resident of surgery department of Branch No 2 «425 VG» Clinic, Russia, 660017, Krasnoyarsk, Gorky str., 2, tel. +7-911-821-32-23, e-mail: ximikatu@mail.ru

Abstract. One of the causes of early deforming arthrosis after ankle joint injury is persistent subluxation of the foot outwards. The recurrence of subluxation with distal tibiofibular syndesmosis leak after ankle fracture treatment is about 4,7%. Aim. The aim of the study was to demonstrate the possibilities of shortening plastics in distal tibiofibular syndesmosis anterior portion in foot subluxation reccurence after surgical treatment of a patient with ankle fracture.Material and methods. The technique of distal intertibial syndesmosis anterior portion shortening plastics in foot subluxation recurrence is presented. Foot and ankle joint disease clinical evaluation scale of the American Orthopedic Foot Association (AOFAS) was applied to assess the outcomes of treatment. Results and discussion. The patient wasre-examined 4 months after the surgery. Ankle joint X-ray was performed. It showed no foot subluxation recurrence. The range of motion in the ankle joint: plantar flexion – 120°, dorsal flexion – 78°. The clinical outcome according to the AOFAS scale was 75 points. Thus, it is possible to consider the achieved outcome of treatment as good. Conclusion.Distal intertibial syndesmosis anterior portion shortening plastics in foot subluxation recurrence contributes to ankle joint fork width maintenance after removing the screws fixing the distal intertibial syndesmosis, which allows to improve long-term functional outcomes and to reduce the risk of deforming arthrosis.

Key words: ankle joint, foot subluxation, syndesmosis, posttraumatic ankle joint arthrosis.

For reference: Mikhailov SV, Khominets VV, Shakun DA, Shchukin AV, Foos IV, Komarov AV. Surgical treatment of the leak of distal tibiofibular syndesmosis after ankle fracture: clinical case. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 78-82. DOI: 10.20969/VSKM.2019.12(3).78-82.

REFERENCES

1. Sagi HC, Shah AR, Sanders RW. The Functional Consequence of Syndesmotic Joint Malreduction at a Minimum 2-Year Follow-Up. J Orthop Trauma. 2012; 26 (7): 439–443.

2. Weening B, Bhandari M. Predictors of functional outcome following transsyndesmotic screw fixation of ankle fractures. J Orthop Trauma. 2005; 19 (2): 102–108.

3. Lübbeke A, Salvo D, Stern R, Hoffmeyer P, Holzer N, Assal M. Risk factors for post-traumatic osteoarthritis of the ankle: an eighteen year follow-up study. Int Orthop. 2012; 36 (7): 1403–1410. doi: 10.1007/s00264-011-1472-7.

4. Khominets VV, Mikhailov SV, Shapovalov VM. Perelomy distal’nogo otdela kostey goleni (mekhanizm, diagnostika, printsipy konservativnogo i operativnogo lecheniya – vtoroye izdaniye [Fractures of the distal leg bone (mechanism, diagnosis, principles of conservative and operative treatment – second edition]. SPb: Sintez Byk [SPb: Synthesis Buk]. 2016; 168 p.

5. Tikhilov RM, Koryshkov NA, Yemelyanov V, Stoyanov AV, Zhuravlev AV, Privalov AM. Opyt endoprotezirovaniya golenostopnogo sustava v Rossiyskom nauchnoissledovatel’skom institute travmatologii i ortopedii imeni RR Vreden [Experience of ankle joint endoprosthetics at the Russian Research Institute of Traumatology and Orthopedics named after RR Vreden]. Vestnik Travmatologii i ortopedii imeni NN Priorova [Bulletin of Traumatology and Orthopedics named after NN Priorov]. 2009; 3: 56-60.

6. Elgafy H, Semann HB, Blessinger B, et al. Computed tomography of normal distal tibiofi bular Syndesmosis. Skeletal Radiol. 2010; 39 (6): 559–564. 

7. Egol KA, Pahk B, Walsh M, et al. Outcome after unstable ankle fracture: effect of Syndesmosis stabilization. J Orthop Trauma. 2010; 24 (1): 7–11.

8. Gardner MJ, Demetrakopoulos D, Briggs SM, et al. Malreduction of the tibiofi bular syndesmosis in ankle fractures. Foot Ankle Int. 2006; 27: 788–792.

9. Swords MP, Sands AK, Shank JR. Late treatment of syndesmotic injuries. Foot Ankle Clin. 2017; 22 (1): 65–75. 

10. Miller AN, Carroll EA, Parker RJ, et al. Direct visualization for syndesmotic stabilization of ankle fractures. Foot Ankle Int. 2009; 30: 419–426.

11. Nielson JH, Gardner MJ, Peterson MG, Sallis JG, Potter HG, Helfet DL, Lorich DG. Radiographic measurements do not predict syndesmotic injury in ankle fractures: an MRI study. Clin Orthop Relat Res. 2005; 436: 216–221.

12. Grass R, Rammelt S, Biewener A, et al. Peroneus longus ligamentoplasty for chronic instability of the distal tibiofi bular Syndesmosis. Foot Ankle Int. 2003; 24 (5): 392–397.

 

UDC 616.716.1-006.2-053.2

DOI: 10.20969/VSKM.2019.12(3).83-88

PDF download RADICULAR CYST IN THE PRACTICE OF PEDIATRIC DENTIST, MANAGEMENT PLAN

MODINA TAMARA N., ORCID: 0000-0002-2036-9464; D. Med. Sci., professor of the Department of maxillofacial surgery and dentistry of Institute of advanced physician training of National Medical and Surgical Center named after N.I. Pirogov, Russia, Moscow, tel. +7-910-420-50-04, e-mail: tnmodina@mail.ru

TSINECKER DINA A., ORCID: 0000-0002-8366-5731; C. Med. Sci., associate professor of the Department of pediatric dentistry of Kazan State Medical University, Russia, Kazan, tel. +7-903-341-46-46, e-mail: dzinecker@mail.ru

TSINECKER DARIA T., ORCID: 0000-0001-6635-0941; 5th year student of Dental faculty of Pavlov First Saint Petersburg State Medical University, Russia, Saint Petersburg, tel. +7-967-343-43-90, e-mail: daschaz@inbox.ru

KUZNETSOV EVGENIY A., ORCID: 0000-0002-0775-3596; 5th year student of Dental faculty of Pavlov First Saint Petersburg State Medical University, Russia, Saint Petersburg, tel. +7-921-554-95-05, e-mail: kyznezovg95@mail.ru

Abstract. Jaw cyst treatment in modern reality when patients demand quick rehabilitation process and maintaining aesthetics throughout the treatment, require modern methods of diagnosis (computed tomography) as well as the new approaches to surgical treatment. Aim. The aim of the study was to determine a management plan for a pediatric dentist in 16-year-old girl presenting with upper jaw radicular cyst, demonstrating the stages of treatment and follow-up. Considering this clinical case as an example, correct management plan was important to avoid child abutment teeth damage. Complete diagnosis of this disease is possible only via clinical, radiological examination and joint interdisciplinary consultation. The interdisciplinary work of a pediatric dentist, a surgeon, an orthopedic surgeon, as well as timely cytological material study is extremely important in management and treatment plan in order to achieve oncologic alertness and to prevent early teeth loss. Material and methods. A clinical case of 16 year old patient diagnosed with upper jaw radicular cyst. Medical and life history, clinical x-ray, histological (fluid cytology) and cytological studies were applied. During the management period, a joint consultation of maxillofacial surgeon, orthopedic surgeon (impression taking), endodontic treatment, including root canals instrumental treatment, endo-canal and periapical tissue sampling, histological study, temporary root canal filling, temporary filling setting, followed (second visit) by three-dimensional root canal obturation, clinical and radiological studies, cystectomy, root tip resection in teeth 1.1 and 1.2, and control clinical and radiological study 3 months after surgery. Results and discussion. Thus, the example of this clinical case of a patient with a diagnosis of upper jaw radicular cyst allows one to emphasize that the correct management plan is important to avoid child abutment teeth damage. Such cases are less common in the practice of pediatric dentist. Diagnosis of this disease in full is possible only via clinical and radiological examination and joint interdisciplinary consultation. Conclusion. The interdisciplinary work of the pediatric dentist, surgeon, orthopedic surgeon, as well as the timely cytological material study is extremely important in management and treatment plan in order to achieve oncologic alertness and to prevent early teeth loss. The period of complete rehabilitation in patients with jaw cysts is quite long, taking from 1 to 2 years.

Key words: jaw cysts, radicular cyst, cyst treatment.

For reference: Modina TN, Tsinecker DA, Tsinecker DT, Kuznetsov EA. Radicular cyst in the practice of pediatric dentist. Management plan. The Bulletin of Contemporary Clinical Medicine. 2019; 12 (3): 83-88. DOI: 10.20969/ VSKM.2019.12(3).83-88.

REFERENCES

1. Korsak AK. Opukholi chelyustno-litsevoĭ oblasti u deteĭ: monografiya [Tumors of the maxillofacial region in children: monograph]. Ufa: Bashkirskiy GMU [Ufa: Bashkir State Medical University]. 2002; 2: 32–46.

2. Kolesov AA, Vorob’yev YuI, Kasparova NN. Novoobrazovaniya myagkikh tkaneĭ i kosteĭ litsa u deteĭ i podrostkov [Neoplasms of soft tissues and bones of the face in children and adolescents]. Moskva: Meditsina [Moscow: Medicine]. 1989; 211–259.

3. Nigel R Johnson, et al. Frequency of odontogenic cyst and tumors: a systematic review. Journal of investigative and clinical dentistry. 2014; 5 (1): 9-14.

4. Paul JW Stoelinga. The Management of Aggressive Cysts of the Jaws. Journal Maxillofac Oral Surg. 2012; 11 (1): 2-12.

5. Bodner L, et al. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases. J Pathol Med. 2011; 10: 733-738.

6. Bernadskiy YuI. Osnovy chelyustno-litsevoy khirurgii i khirurgicheskoy stomatologii [Fundamentals of maxillofacial surgery and surgical dentistry]. Vitebsk: Belmedkniga [Vitebsk: Belmedkniga]. 1998; 3: 416 р.

7. Kushner AN, Lapkovskiy VI, Petrovich NI. Odontogennyye kisty u detey: epidemiologiya i lecheniye [Odontogenic cysts in children: epidemiology and treatment]. Sovremennaya stomatologiya [Modern dentistry]. 2013; 2 (57): 67-68.

8. VOZ [WHO]. Adaptirovannyĭ variant Mezhdunarodnoĭ klassifikatsii bolezneĭ dlya primeneniya v stomatologii: MKB-S [The adapted version of the International Classification of Diseases for use in stomatology: ICD-S]. Katalogizatsiya publikatsiĭ; Bibliotechnaya sluzhba VOZ [Cataloging publications; WHO library service]. 1997; 3: 66–73.

9. Panin AM, Kim LYe, Yurkevich RI. Khirurgicheskaya reabilitatsiya patsiyentov s radikulyarnymi kistami chelyustey [Surgical rehabilitation of patients with radicular cysts of the jaws]. Palliativnaya meditsina i reabilitatsiya [Palliative Medicine and Rehabilitation]. 2015; 1: 28-29.

10. Tsinekker DA. Osobennosti khronicheskogo gipertroficheskogo gingivita u podrostkov 13-15 let [Features of chronic hypertrophic gingivitis in adolescents 13-15 years old]. Kazan’: Kazanskiy GMU [Kazan: Kazan State Medical University]. 2013; 131 p.

11. Mamayeva YeV. Parodontologicheskiy status i funktsional’noye sostoyaniye organizma u podrostkov [Periodontal status and functional status of the body in adolescents]. Moskva: Tsentral’nyy nauchno – issledovatel’skiy institut stomatologii Roszdrava [Moscow: Federal State Institution Central Scientific Research Institute of Dentistry of Roszdrav]. 2007; 196 p.

12. Amkhadova MA, Soykher MI, Chuyanova YeYu. Onkonastorozhennost’ v praktike vracha-stomatologa [Onconstruction in the practice of a dentist]. Meditsinskiy alfavit [Medical Alphabet]. 2016; 9 (272): 7.

13. Raad ZK, Veselova TV, Biabi A. Osteoplasticheskoye zameshcheniye defektov chelyusteĭ pri lechenii odontogennykh kist [Osteoplastic replacement of jaw defects in the treatment of odontogenic cysts]. Institut Stomatologii [Institute of Dentistry]. 2014; 2 (63): 36-38.